BDBM27193 (1R,2S,5S,6S,9R,12S,13R,16S)-N,N,6,7,13-pentamethyl-7-azapentacyclo[10.8.0.0^{2,9}.0^{5,9}.0^{13,18}]icos-18-en-16-amine::Conessine

SMILES [H][C@@]1(C)N(C)C[C@]23CC[C@@]4([H])[C@@]([H])(CC=C5C[C@H](CC[C@]45C)N(C)C)[C@]2([H])CC[C@]13[H]

InChI Key InChIKey=GPLGAQQQNWMVMM-MYAJQUOBSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 27193   

TargetHistamine H3 receptor(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM27193((1R,2S,5S,6S,9R,12S,13R,16S)-N,N,6,7,13-pentamethy...)
Affinity DataKi:  5.37nM ΔG°:  -11.3kcal/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM27193((1R,2S,5S,6S,9R,12S,13R,16S)-N,N,6,7,13-pentamethy...)
Affinity DataKi:  5.37nMAssay Description:Displacement of [3H]N-alpha methyl histamine from human cloned histamine H3 receptor expressed in C6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbott Laboratories

LigandPNGBDBM27193((1R,2S,5S,6S,9R,12S,13R,16S)-N,N,6,7,13-pentamethy...)
Affinity DataKi:  24.5nMAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbott Laboratories

LigandPNGBDBM27193((1R,2S,5S,6S,9R,12S,13R,16S)-N,N,6,7,13-pentamethy...)
Affinity DataKi:  25nMAssay Description:Displacement of [3H]N-alpha methyl histamine from rat cortical membrane histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbott Laboratories

LigandPNGBDBM27193((1R,2S,5S,6S,9R,12S,13R,16S)-N,N,6,7,13-pentamethy...)
Affinity DataKi:  66nMAssay Description:Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM27193((1R,2S,5S,6S,9R,12S,13R,16S)-N,N,6,7,13-pentamethy...)
Affinity DataKi: >1.00E+4nMAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM27193((1R,2S,5S,6S,9R,12S,13R,16S)-N,N,6,7,13-pentamethy...)
Affinity DataKi: >1.00E+4nM ΔG°: >-6.82kcal/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM27193((1R,2S,5S,6S,9R,12S,13R,16S)-N,N,6,7,13-pentamethy...)
Affinity DataKi: >1.00E+4nM ΔG°: >-6.82kcal/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed