BDBM50029764 1,1'-sulfonylbis(4-aminobenzene)::4,4'-Sulfonylbisbenzenamine::4,4'-dapsone::4,4'-diaminodiphenyl sulfone::4,4'-sulfonylbisaniline::4,4'-sulfonyldianiline::4-aminophenyl sulfone::Bis(p-aminophenyl) sulfone::CHEMBL1043::DADPS::DAPSONE::DDS::Diaphenylsulfone::p,p'-diaminodiphenyl sulfone::p,p-sulphonylbisbenzamine::p,p-sulphonylbisbenzenamine::p-aminophenyl sulfone

SMILES Nc1ccc(cc1)S(=O)(=O)c1ccc(N)cc1

InChI Key InChIKey=MQJKPEGWNLWLTK-UHFFFAOYSA-N

Data  1 KI  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50029764   

Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Chemical Diversity Research Institute (Cdri)

Curated by ChEMBL
LigandPNGBDBM50029764(1,1'-sulfonylbis(4-aminobenzene) | 4,4'-Sulfonylbi...)
Affinity DataKi:  183nMAssay Description:Antagonist activity at recombinant human 5-HT6 receptor expressed in HEK293 cells assessed as 5-HT-induced intracellular cAMP production after 30 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Rattus norvegicus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50029764(1,1'-sulfonylbis(4-aminobenzene) | 4,4'-Sulfonylbi...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate up...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50029764(1,1'-sulfonylbis(4-aminobenzene) | 4,4'-Sulfonylbi...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50029764(1,1'-sulfonylbis(4-aminobenzene) | 4,4'-Sulfonylbi...)
Affinity DataIC50: >1.35E+5nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50029764(1,1'-sulfonylbis(4-aminobenzene) | 4,4'-Sulfonylbi...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50029764(1,1'-sulfonylbis(4-aminobenzene) | 4,4'-Sulfonylbi...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50029764(1,1'-sulfonylbis(4-aminobenzene) | 4,4'-Sulfonylbi...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50029764(1,1'-sulfonylbis(4-aminobenzene) | 4,4'-Sulfonylbi...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
University Sarajevo School Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50029764(1,1'-sulfonylbis(4-aminobenzene) | 4,4'-Sulfonylbi...)
Affinity DataIC50:  420nMAssay Description:Inhibition of MPO (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDihydrofolate reductase(Pneumocystis carinii)
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50029764(1,1'-sulfonylbis(4-aminobenzene) | 4,4'-Sulfonylbi...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibitory activity was determined against dihydrofolate reductase in Pneumocystis carinii .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50029764(1,1'-sulfonylbis(4-aminobenzene) | 4,4'-Sulfonylbi...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed