BDBM50057583 4-[3-Difluoromethyl-5-(3-fluoro-4-methoxy-phenyl)-pyrazol-1-yl]-benzenesulfonamide::CHEMBL28636::Deracoxib

SMILES COc1ccc(cc1F)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)F

InChI Key InChIKey=WAZQAZKAZLXFMK-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50057583   

TargetProstaglandin G/H synthase 1(Canis familiaris)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50057583(4-[3-Difluoromethyl-5-(3-fluoro-4-methoxy-phenyl)-...)
Affinity DataIC50:  2.30E+4nMAssay Description:In vitro inhibitory activity against cannine prostaglandin G/H synthase 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50057583(4-[3-Difluoromethyl-5-(3-fluoro-4-methoxy-phenyl)-...)
Affinity DataIC50:  3.60E+4nMAssay Description:In vitro inhibitory concentration required to block recombinant human prostaglandin G/H synthase 1 (COX-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50057583(4-[3-Difluoromethyl-5-(3-fluoro-4-methoxy-phenyl)-...)
Affinity DataIC50:  2.02E+4nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Canis familiaris)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50057583(4-[3-Difluoromethyl-5-(3-fluoro-4-methoxy-phenyl)-...)
Affinity DataIC50:  630nMAssay Description:In vitro inhibitory activity against cannine prostaglandin G/H synthase 2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50057583(4-[3-Difluoromethyl-5-(3-fluoro-4-methoxy-phenyl)-...)
Affinity DataIC50:  50.1nMAssay Description:Inhibition of human Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50057583(4-[3-Difluoromethyl-5-(3-fluoro-4-methoxy-phenyl)-...)
Affinity DataIC50:  50nMAssay Description:In vitro inhibitory concentration required to block human recombinant prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed