BDBM50024894 (1R, 2S)-1,2-epoxypropyl-phosphonic acid::(2R,3S)-3-methyloxiran-2-ylphosphonate::(2R,3S)-3-methyloxiran-2-ylphosphonic acid::(3-Methyl-oxiranyl)-phosphonic acid(Na salt)::CHEMBL1757::FOSFOMYCIN::Fosfomycin (compound 1)::Fosfomycin Calcium::Fosfomycin Sodium::Monurol::phosphomycin

SMILES C[C@@H]1O[C@@H]1P(O)(O)=O

InChI Key InChIKey=YMDXZJFXQJVXBF-STHAYSLISA-N

Data  6 IC50

PDB links: 14 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50024894   

TargetUDP-N-acetylglucosamine 1-carboxyvinyltransferase(Escherichia coli K-12 (Enterobacteria))
University Of Ljubljana

LigandPNGBDBM50024894((1R, 2S)-1,2-epoxypropyl-phosphonic acid | (2R,3S)...)
Affinity DataIC50:  8.80E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetUDP-N-acetylglucosamine 1-carboxyvinyltransferase(Escherichia coli K-12 (Enterobacteria))
University Of Ljubljana

LigandPNGBDBM50024894((1R, 2S)-1,2-epoxypropyl-phosphonic acid | (2R,3S)...)
Affinity DataIC50:  118nMAssay Description:Inhibition of Escherichia coli K12 Mur A in presence of UNAGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetUDP-N-acetylglucosamine 1-carboxyvinyltransferase(Escherichia coli K-12 (Enterobacteria))
University Of Ljubljana

LigandPNGBDBM50024894((1R, 2S)-1,2-epoxypropyl-phosphonic acid | (2R,3S)...)
Affinity DataIC50:  5.30E+3nMAssay Description:Inhibition of wild type his tagged Escherichia coli K12 MurA using UDP-N-acetylglucosamine as substrate preincubated with substrate for 30 mins prior...More data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetUDP-N-acetylglucosamine 1-carboxyvinyltransferase(Escherichia coli K-12 (Enterobacteria))
University Of Ljubljana

LigandPNGBDBM50024894((1R, 2S)-1,2-epoxypropyl-phosphonic acid | (2R,3S)...)
Affinity DataIC50:  100nMAssay Description:Inhibition of Escherichia coli MurA expressed in Escherichia coli BL21(lamdaDE3) using UNAG and PEP as substrate incubated for 10 mins prior to PEP a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetUDP-N-acetylglucosamine 1-carboxyvinyltransferase(Escherichia coli K-12 (Enterobacteria))
University Of Ljubljana

LigandPNGBDBM50024894((1R, 2S)-1,2-epoxypropyl-phosphonic acid | (2R,3S)...)
Affinity DataIC50:  8.80E+3nMAssay Description:Inhibition of Escherichia coli K-12 MBP-fused C-terminal His-tagged MurA (6508 to 7768 residues) using UNAG as substrate preincubated for 10 mins fol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetUDP-N-acetylglucosamine 1-carboxyvinyltransferase(Pseudomonas aeruginosa (G-proteobacteria))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50024894((1R, 2S)-1,2-epoxypropyl-phosphonic acid | (2R,3S)...)
Affinity DataIC50:  1.05E+4nMAssay Description:Inhibition of Pseudomonas aeruginosa PAO1293 MurA in presence of UNAGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed