BDBM50134315 7-hydroxy-11-hydroxymethyl-12-methyl-14,15-dithia-9,12-diazatetracyclo[9.2.2.01,9.03,8]pentadeca-3,5-diene-10,13-dione::CHEMBL331627::GLIOTOXIN

SMILES CN1C(=O)[C@]23CC4=CC=C[C@H](O)[C@H]4N2C(=O)[C@@]1(CO)SS3

InChI Key InChIKey=FIVPIPIDMRVLAY-RBJBARPLSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50134315   

LigandPNGBDBM50134315(7-hydroxy-11-hydroxymethyl-12-methyl-14,15-dithia-...)
Affinity DataIC50:  8.00E+4nMAssay Description:Inhibition of [3H]-FPP incorporation into recombinant human Ha-Ras-CVLS by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetolactate synthase catalytic subunit, mitochondrial(Saccharomyces cerevisiae)
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50134315(7-hydroxy-11-hydroxymethyl-12-methyl-14,15-dithia-...)
Affinity DataIC50:  200nMAssay Description:Inhibition of Saccharomyces cerevisiae acetolactate synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMycothiol S-conjugate amidase(Mycobacterium tuberculosis)
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50134315(7-hydroxy-11-hydroxymethyl-12-methyl-14,15-dithia-...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis mycothiol-S-conjugate amidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50134315(7-hydroxy-11-hydroxymethyl-12-methyl-14,15-dithia-...)
Affinity DataIC50:  6.40E+3nMAssay Description:Inhibition of HMT-G9a using S-adenosylmethionine and biotinylated H3 peptide after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPyruvate kinase PKM(Homo sapiens (Human))
Central University Of Punjab

Curated by ChEMBL
LigandPNGBDBM50134315(7-hydroxy-11-hydroxymethyl-12-methyl-14,15-dithia-...)
Affinity DataIC50:  2.26E+4nMAssay Description:Inhibition of PKM2 (unknown origin) Hie78, Arg73, Thr328 residues by coloroimetric/fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50134315(7-hydroxy-11-hydroxymethyl-12-methyl-14,15-dithia-...)
Affinity DataIC50:  260nMAssay Description:Inhibition of SUV39H1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50134315(7-hydroxy-11-hydroxymethyl-12-methyl-14,15-dithia-...)
Affinity DataIC50:  530nMAssay Description:Inhibition of G9aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50134315(7-hydroxy-11-hydroxymethyl-12-methyl-14,15-dithia-...)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of [3H]-GGPP incorporation into recombinant human Ha-Ras-CVLL by Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50134315(7-hydroxy-11-hydroxymethyl-12-methyl-14,15-dithia-...)
Affinity DataIC50:  510nMAssay Description:Inhibition of petit-LUBAC (unknown origin)-mediated ubiquitylation expressed in Escherichia coli BL21 after 2 hrs in presence of E1, UbcH5c, E3 and u...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50134315(7-hydroxy-11-hydroxymethyl-12-methyl-14,15-dithia-...)
Affinity DataIC50:  1.10E+3nMAssay Description:Activity against FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed