BDBM50013786 1-Methyl-9H-beta-carboline::1-Methyl-9H-beta-carboline (Harman)::1-Methyl-beta-carboline::1-methyl-9H-pyrido[3,4-b]indole::CHEMBL12014::HARMAN::Harmane::cid_5281404

SMILES Cc1nccc2c3ccccc3[nH]c12

InChI Key InChIKey=PSFDQSOCUJVVGF-UHFFFAOYSA-N

Data  1 KI  3 IC50  1 EC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50013786   

TargetCytochrome P450 2D6(Homo sapiens (Human))
Institut F£R Toxikologie

Curated by ChEMBL
LigandPNGBDBM50013786(1-Methyl-9H-beta-carboline | 1-Methyl-9H-beta-carb...)
Affinity DataKi:  8.60E+4nMAssay Description:Inhibitory effect on Bufuralol 1'-hydroxylation by human liver microsomes (Ki = apparent inhibition constant)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Nanjing Medical University

Curated by ChEMBL
LigandPNGBDBM50013786(1-Methyl-9H-beta-carboline | 1-Methyl-9H-beta-carb...)
Affinity DataIC50:  6.31E+3nMAssay Description:Inhibition of TDO (unknown origin) assessed as reduction in N-formylkynurenine formation using L-tryptophan as substrate incubated for 75 mins by UV ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetChitinase(Onchocerca volvulus)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50013786(1-Methyl-9H-beta-carboline | 1-Methyl-9H-beta-carb...)
Affinity DataIC50:  7.33E+3nMAssay Description:Inhibition of L3 larval stage of Onchocerca volvulus chitinase using 4-methylumbelliferyl-N-N'-N''-beta-chitotrioside as substrate assessed as releas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 11(Homo sapiens (Human))
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM50013786(1-Methyl-9H-beta-carboline | 1-Methyl-9H-beta-carb...)
Affinity DataEC50: >3.50E+5nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Naresuan University

Curated by ChEMBL
LigandPNGBDBM50013786(1-Methyl-9H-beta-carboline | 1-Methyl-9H-beta-carb...)
Affinity DataIC50:  2.09E+4nMAssay Description:Inhibition of electric eel AChE using acetylcholine iodide as substrate measured every 5 sec for 2 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed