BDBM25766 (2R,3S)-5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol::CHEMBL649::Corgard::Nadolol::Solgol::cid_39147

SMILES CC(C)(C)NCC(O)COc1cccc2C[C@@H](O)[C@@H](O)Cc12

InChI Key InChIKey=VWPOSFSPZNDTMJ-UCWKZMIHSA-N

Data  1 KI  1 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 25766   

TargetFatty acid-binding protein, liver(Rattus norvegicus (Rat))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM25766((2R,3S)-5-[3-(tert-butylamino)-2-hydroxypropoxy]-1...)
Affinity DataKi:  2.31E+6nMAssay Description:Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP high binding affinity site expressed in Escherichia coli BL21 by co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
University Of Nottingham

LigandPNGBDBM25766((2R,3S)-5-[3-(tert-butylamino)-2-hydroxypropoxy]-1...)
Affinity DataKd:  2.5nMAssay Description:The whole cell-binding studies were undertaken in CHO cell lines stably expressing each beta-adrenoceptor subtype. Nonspecific binding was determined...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM25766((2R,3S)-5-[3-(tert-butylamino)-2-hydroxypropoxy]-1...)
Affinity DataIC50: >5.00E+4nMAssay Description:The Cdc25B Phosphatase HTS dose response confirmation has been developed to confirm actives identified in the Cdc25B HTS AID 368, screened at the Uni...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
University Of Nottingham

LigandPNGBDBM25766((2R,3S)-5-[3-(tert-butylamino)-2-hydroxypropoxy]-1...)
Affinity DataKd:  59nMpH: 7.4 T: 2°CAssay Description:The whole cell-binding studies were undertaken in CHO cell lines stably expressing each beta-adrenoceptor subtype. Nonspecific binding was determined...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
University Of Nottingham

LigandPNGBDBM25766((2R,3S)-5-[3-(tert-butylamino)-2-hydroxypropoxy]-1...)
Affinity DataKd:  661nMAssay Description:The whole cell-binding studies were undertaken in CHO cell lines stably expressing each beta-adrenoceptor subtype. Nonspecific binding was determined...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed