BDBM50008999 5-Methyl-2-[2-(naphthalen-2-yloxy)-ethyl]-2,4-dihydro-pyrazol-3-one::5-Methyl-2-[2-(naphthalen-2-yloxy)-ethyl]-2,4-dihydro-pyrazol-3-one( nafazatrom)::5-Methyl-2-[2-(naphthalen-2-yloxy)-ethyl]-2,4-dihydro-pyrazol-3-one(nafazatrom)::CHEMBL8425::Nafazatrom

SMILES Cc1cc(=O)n(CCOc2ccc3ccccc3c2)[nH]1

InChI Key InChIKey=INCLABAHEPQBCG-UHFFFAOYSA-N

Data  7 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50008999   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Centre De Recherches De Vitry

Curated by ChEMBL
LigandPNGBDBM50008999(5-Methyl-2-[2-(naphthalen-2-yloxy)-ethyl]-2,4-dihy...)
Affinity DataIC50:  1.00E+4nMAssay Description:In vitro inhibition of 5-lipoxygenase in rat (peritoneal assay)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Centre De Recherches De Vitry

Curated by ChEMBL
LigandPNGBDBM50008999(5-Methyl-2-[2-(naphthalen-2-yloxy)-ethyl]-2,4-dihy...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of 5-lipoxygenase in rat RBL-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50008999(5-Methyl-2-[2-(naphthalen-2-yloxy)-ethyl]-2,4-dihy...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of [14C]-arachidonic acid conversion to 5-HETE by broken cell 5-LO isolated from guinea pig PMNMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50008999(5-Methyl-2-[2-(naphthalen-2-yloxy)-ethyl]-2,4-dihy...)
Affinity DataEC50: >3.72E+5nMAssay Description:Ex vivo inhibition of LTB4 production was measured in dog bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Centre De Recherches De Vitry

Curated by ChEMBL
LigandPNGBDBM50008999(5-Methyl-2-[2-(naphthalen-2-yloxy)-ethyl]-2,4-dihy...)
Affinity DataIC50:  2.50E+3nMAssay Description:Iin vitro inhibition of 5-lipoxygenase activity in rat basophil leukemia type 1(RBL1) cell homogenates, (reduction of [14C]-5-HETE formation)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Centre De Recherches De Vitry

Curated by ChEMBL
LigandPNGBDBM50008999(5-Methyl-2-[2-(naphthalen-2-yloxy)-ethyl]-2,4-dihy...)
Affinity DataIC50:  5.00E+4nMAssay Description:In vitro inhibition of LTB4 production was measured in rat bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(RAT)
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50008999(5-Methyl-2-[2-(naphthalen-2-yloxy)-ethyl]-2,4-dihy...)
Affinity DataIC50: >1.00E+5nMAssay Description:In vitro inhibition of PGE-2 production was measured in rat bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(RAT)
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50008999(5-Methyl-2-[2-(naphthalen-2-yloxy)-ethyl]-2,4-dihy...)
Affinity DataIC50: >5.00E+4nMAssay Description:In vitro for prostaglandin G/H synthase inhibitory activity against rat basophil leukemia type 1 cell homogenates, by measuring the radioactivity of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed