BDBM50152769 CHEMBL410972::GLP-1(7-36)-NH2::GLP-17-(7-36) derivative::NH2-HAEGTFTSDVSSYLEGQAAKEFIAWLVKGR-CONH2

SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(N)=O

InChI Key InChIKey=DTHNMHAUYICORS-KTKZVXAJSA-N

Data  5 IC50  19 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50152769   

TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Tufts University

Curated by ChEMBL
LigandPNGBDBM50152769(CHEMBL410972 | GLP-1(7-36)-NH2 | GLP-17-(7-36) der...)
Affinity DataEC50:  0.350nMAssay Description:Agonist activity at human GLP-1R expressed in African green monkey COS7 cells assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Tufts University

Curated by ChEMBL
LigandPNGBDBM50152769(CHEMBL410972 | GLP-1(7-36)-NH2 | GLP-17-(7-36) der...)
Affinity DataEC50:  25nMAssay Description:Agonist activity at human GLP-1R expressed in CHO cells coexpressing beta-arrestin-2 assessed as increase in beta arrestin-2 recruitment incubated fo...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Tufts University

Curated by ChEMBL
LigandPNGBDBM50152769(CHEMBL410972 | GLP-1(7-36)-NH2 | GLP-17-(7-36) der...)
Affinity DataIC50:  0.140nMAssay Description:Inhibitory concentration against human GLP1 receptor expressed in CHO cell membrane homogenates with 1%DMSOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Tufts University

Curated by ChEMBL
LigandPNGBDBM50152769(CHEMBL410972 | GLP-1(7-36)-NH2 | GLP-17-(7-36) der...)
Affinity DataEC50:  0.400nMAssay Description:Effective concentration against human GLP1 receptor expressed in CHO cells with 1%DMSOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Tufts University

Curated by ChEMBL
LigandPNGBDBM50152769(CHEMBL410972 | GLP-1(7-36)-NH2 | GLP-17-(7-36) der...)
Affinity DataEC50:  15nMAssay Description:Effective concentration against human GLP1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Tufts University

Curated by ChEMBL
LigandPNGBDBM50152769(CHEMBL410972 | GLP-1(7-36)-NH2 | GLP-17-(7-36) der...)
Affinity DataIC50:  1.90nMAssay Description:Displacement of [125I]exendin(9-39) from human GLP1R expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Tufts University

Curated by ChEMBL
LigandPNGBDBM50152769(CHEMBL410972 | GLP-1(7-36)-NH2 | GLP-17-(7-36) der...)
Affinity DataEC50:  1nMAssay Description:Agonist activity at human GLP1R expressed in CHO cells assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Tufts University

Curated by ChEMBL
LigandPNGBDBM50152769(CHEMBL410972 | GLP-1(7-36)-NH2 | GLP-17-(7-36) der...)
Affinity DataIC50:  1.5nMAssay Description:Displacement of [125I]-exendin (9 to 39) from human GLP-1R expressed in African green monkey COS7 cells by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Tufts University

Curated by ChEMBL
LigandPNGBDBM50152769(CHEMBL410972 | GLP-1(7-36)-NH2 | GLP-17-(7-36) der...)
Affinity DataEC50:  0.0440nMAssay Description:Agonist activity at human GLP1 receptor expressed in HEK293 cells harboring mCerulean and mCitrine fused Epac protein assessed as increase in cAMP le...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Tufts University

Curated by ChEMBL
LigandPNGBDBM50152769(CHEMBL410972 | GLP-1(7-36)-NH2 | GLP-17-(7-36) der...)
Affinity DataEC50:  0.000900nMAssay Description:Agonist activity at human GLP-1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon-like peptide 1 receptor(Mus musculus)
Sanofi-Aventis Deutschland

Curated by ChEMBL
LigandPNGBDBM50152769(CHEMBL410972 | GLP-1(7-36)-NH2 | GLP-17-(7-36) der...)
Affinity DataEC50:  0.000900nMAssay Description:Agonist activity at mouse GLP-1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Mus musculus)
Sanofi-Aventis Deutschland

Curated by ChEMBL
LigandPNGBDBM50152769(CHEMBL410972 | GLP-1(7-36)-NH2 | GLP-17-(7-36) der...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at mouse glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Sanofi-Aventis Deutschland

Curated by ChEMBL
LigandPNGBDBM50152769(CHEMBL410972 | GLP-1(7-36)-NH2 | GLP-17-(7-36) der...)
Affinity DataEC50: >0.00100nMAssay Description:Agonist activity at human glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Tufts University

Curated by ChEMBL
LigandPNGBDBM50152769(CHEMBL410972 | GLP-1(7-36)-NH2 | GLP-17-(7-36) der...)
Affinity DataEC50:  0.00300nMAssay Description:Activation of human GLP-1 receptor overexpressed in HEK293 cells assessed as cAMP accumulation after 20 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Tufts University

Curated by ChEMBL
LigandPNGBDBM50152769(CHEMBL410972 | GLP-1(7-36)-NH2 | GLP-17-(7-36) der...)
Affinity DataEC50:  0.0501nMAssay Description:Agonist activity at human GLP1 receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 24 hrs by luciferase reporter gene ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Tufts University

Curated by ChEMBL
LigandPNGBDBM50152769(CHEMBL410972 | GLP-1(7-36)-NH2 | GLP-17-(7-36) der...)
Affinity DataEC50:  4nMAssay Description:Agonist activity at Rluc8 fused human GLP1 receptor expressed in HEK293 cells assessed co-expressing GFP-tagged beta-arrestin1 assessed as increase i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Tufts University

Curated by ChEMBL
LigandPNGBDBM50152769(CHEMBL410972 | GLP-1(7-36)-NH2 | GLP-17-(7-36) der...)
Affinity DataEC50:  7.90nMAssay Description:Agonist activity at Rluc8 fused human GLP1 receptor expressed in HEK293 cells assessed co-expressing GFP-tagged beta-arrestin2 assessed as increase i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Tufts University

Curated by ChEMBL
LigandPNGBDBM50152769(CHEMBL410972 | GLP-1(7-36)-NH2 | GLP-17-(7-36) der...)
Affinity DataEC50:  0.0840nMAssay Description:Agonist activity at human GLP-1R expressed in HEK293 cells assessed as cAMP release incubated for 20 min by HTRF analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Tufts University

Curated by ChEMBL
LigandPNGBDBM50152769(CHEMBL410972 | GLP-1(7-36)-NH2 | GLP-17-(7-36) der...)
Affinity DataEC50:  0.00600nMAssay Description:Agonist activity at human GLP1R expressed in frozen cells assessed as increase in cAMP production measured after 1 hr by HitHunter luminescence assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Tufts University

Curated by ChEMBL
LigandPNGBDBM50152769(CHEMBL410972 | GLP-1(7-36)-NH2 | GLP-17-(7-36) der...)
Affinity DataIC50:  7.90nMAssay Description:Binding affinity to human GLP-1R expressed in CHO cells coexpressing beta-arrestin-2 incubated for 1 hr by time-resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Tufts University

Curated by ChEMBL
LigandPNGBDBM50152769(CHEMBL410972 | GLP-1(7-36)-NH2 | GLP-17-(7-36) der...)
Affinity DataEC50:  0.00159nMAssay Description:Agonist activity at human GLP-1R expressed in CHO cells coexpressing beta-arrestin-2 assessed as reduction in cAMP accumulation incubated for 2 hrs u...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Tufts University

Curated by ChEMBL
LigandPNGBDBM50152769(CHEMBL410972 | GLP-1(7-36)-NH2 | GLP-17-(7-36) der...)
Affinity DataEC50:  794nMAssay Description:Agonist activity at human GLP-1R expressed in CHO cells coexpressing beta-arrestin-2 assessed as stimulation intracellular calcium mobilization measu...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Tufts University

Curated by ChEMBL
LigandPNGBDBM50152769(CHEMBL410972 | GLP-1(7-36)-NH2 | GLP-17-(7-36) der...)
Affinity DataEC50:  100nMAssay Description:Agonist activity at human GLP-1R assessed as increase in ERK1/2 phosphorylation at Thr202/Tyr204 residues incubated for 20 mins by AlphaLISA assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Tufts University

Curated by ChEMBL
LigandPNGBDBM50152769(CHEMBL410972 | GLP-1(7-36)-NH2 | GLP-17-(7-36) der...)
Affinity DataIC50:  14nMAssay Description:Inhibitory concentration required against human GLP1 receptor expressed in CHO cell membrane homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed