BDBM50013876 CHEMBL291278::Methyl aspartic acid::N-Methyl aspartic acid::N-Methyl-D-aspartate::N-Methyl-D-aspartic acid::N-Methylaspartate::NMDA::US9182402, 16

SMILES CN[C@H](CC(O)=O)C(O)=O

InChI Key InChIKey=HOKKHZGPKSLGJE-GSVOUGTGSA-N

Data  3 IC50  4 EC50

PDB links: 3 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50013876   

TargetSerine protease hepsin(Homo sapiens (Human))
Fred Hutchinson Cancer Research Center

US Patent
LigandPNGBDBM50013876(CHEMBL291278 | Methyl aspartic acid | N-Methyl asp...)
Affinity DataIC50:  750nMAssay Description:To identify novel inhibitors of hepsin, the Chembridge DIVERSet 10,000 compound high-diversity library was screened using an assay based on the cleav...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTrypsin(Sus scrofa)
Fred Hutchinson Cancer Research Center

US Patent
LigandPNGBDBM50013876(CHEMBL291278 | Methyl aspartic acid | N-Methyl asp...)
Affinity DataIC50:  2.42E+3nMAssay Description:To identify novel inhibitors of hepsin, the Chembridge DIVERSet 10,000 compound high-diversity library was screened using an assay based on the cleav...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProthrombin(Bos taurus (Bovine))
Fred Hutchinson Cancer Research Center

US Patent
LigandPNGBDBM50013876(CHEMBL291278 | Methyl aspartic acid | N-Methyl asp...)
Affinity DataIC50: >2.00E+4nMAssay Description:To identify novel inhibitors of hepsin, the Chembridge DIVERSet 10,000 compound high-diversity library was screened using an assay based on the cleav...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50013876(CHEMBL291278 | Methyl aspartic acid | N-Methyl asp...)
Affinity DataEC50:  8.30E+3nMAssay Description:Activity at rat NR1/NR2D receptor expressed in Xenopus oocytes assessed as effect on glutamate-induced current by two voltage clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50013876(CHEMBL291278 | Methyl aspartic acid | N-Methyl asp...)
Affinity DataEC50:  2.20E+4nMAssay Description:Activity at rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as effect on glutamate-induced current by two voltage clamp elect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50013876(CHEMBL291278 | Methyl aspartic acid | N-Methyl asp...)
Affinity DataEC50:  2.30E+4nMAssay Description:Activity at rat recombinant NR1/NR2C receptor expressed in Xenopus oocytes assessed as effect on glutamate-induced current by two voltage clamp elect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50013876(CHEMBL291278 | Methyl aspartic acid | N-Methyl asp...)
Affinity DataEC50:  7.50E+4nMAssay Description:Activity at rat recombinant NR1/NR2A receptor expressed in Xenopus oocytes assessed as effect on glutamate-induced current by two voltage clamp elect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed