BDBM50255753 CHEMBL481611::MK-0822::Odanacatib
SMILES CC(C)(F)C[C@H](N[C@@H](c1ccc(cc1)-c1ccc(cc1)S(C)(=O)=O)C(F)(F)F)C(=O)NC1(CC1)C#N
InChI Key InChIKey=FWIVDMJALNEADT-SFTDATJTSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 25 hits for monomerid = 50255753
Affinity DataKi: 0.180nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
Affinity DataKi: 126nMAssay Description:Inhibition of Trypanosoma cruzi cruzain using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by susbtrate addition ...More data for this Ligand-Target Pair
Affinity DataKi: 1.26E+3nMAssay Description:Inhibition of Cathepsin L (unknown origin) using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by susbtrate additi...More data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
Affinity DataIC50: 183nMAssay Description:Inhibition of human recombinant CatS assessed as suppression of enzyme-mediated Z-Val-Val-Arg-AMC cleavage by QFRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of cathepsin SMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of cathepsin LMore data for this Ligand-Target Pair
TargetCathepsin K(Oryctolagus cuniculus (rabbit))
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of rabbit cathepsin KMore data for this Ligand-Target Pair
TargetCathepsin F(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: 795nMAssay Description:Inhibition of cathepsin FMore data for this Ligand-Target Pair
TargetPro-cathepsin H(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: >10nMAssay Description:Inhibition of cathepsin HMore data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
Affinity DataIC50: 4.84E+3nMAssay Description:Inhibition of cathepsin L in human HepG2 cellsMore data for this Ligand-Target Pair
TargetCathepsin B(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: 1.05E+3nMAssay Description:Inhibition of cathepsin B in human HepG2 cellsMore data for this Ligand-Target Pair
TargetCathepsin B(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: 1.03E+3nMAssay Description:Inhibition of cathepsin BMore data for this Ligand-Target Pair
TargetCathepsin L2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: 762nMAssay Description:Inhibition of cathepsin VMore data for this Ligand-Target Pair
Affinity DataIC50: 45nMAssay Description:Inhibition of cathepsin S in human ramos cellsMore data for this Ligand-Target Pair
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: >10nMAssay Description:Inhibition of cathepsin CMore data for this Ligand-Target Pair
TargetCathepsin Z(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: >10nMAssay Description:Inhibition of cathepsin ZMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of Cathepsin K (unknown origin) assessed as inhibition of AFC release using sequence LR labelled with AFC as substrate by fluorescence bas...More data for this Ligand-Target Pair
Affinity DataIC50: <500nMAssay Description:Inhibition of Cathepsin S (unknown origin) assessed as inhibition of AFC release using sequence VVR labelled with AFC as substrate by fluorescence ba...More data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibition of cathepsin KMore data for this Ligand-Target Pair
TargetCathepsin B(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: <2.00E+3nMAssay Description:Inhibition of Cathepsin B (unknown origin) assessed as inhibition of AFC release using sequence RR labelled with AFC as substrate by fluorescence bas...More data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair