BDBM85043 CAS_149017-66-3::CHEMBL69234::NSC_6093163::PPADS

SMILES Cc1nc(N=Nc2ccc(cc2S(O)(=O)=O)S(O)(=O)=O)c(COP(O)(O)=O)c(C=O)c1O

InChI Key InChIKey=PNFZSRRRZNXSMF-UHFFFAOYSA-N

Data  4 KI  15 IC50  14 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 33 hits for monomerid = 85043   

TargetP2X purinoceptor 4(Homo sapiens (Human))
Max-Planck Institute For Experimental Medicine

Curated by PDSP Ki Database
LigandPNGBDBM85043(CAS_149017-66-3 | CHEMBL69234 | NSC_6093163 | PPAD...)
Affinity DataKi:  27.5nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(RAT)
Max-Planck Institute For Experimental Medicine

Curated by PDSP Ki Database
LigandPNGBDBM85043(CAS_149017-66-3 | CHEMBL69234 | NSC_6093163 | PPAD...)
Affinity DataKi:  500nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM85043(CAS_149017-66-3 | CHEMBL69234 | NSC_6093163 | PPAD...)
Affinity DataKi:  3.47E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM85043(CAS_149017-66-3 | CHEMBL69234 | NSC_6093163 | PPAD...)
Affinity DataKi:  4.02E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 2(RAT)
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM85043(CAS_149017-66-3 | CHEMBL69234 | NSC_6093163 | PPAD...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of inward ion current elicited by ATP at P2X2 receptor expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(RAT)
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM85043(CAS_149017-66-3 | CHEMBL69234 | NSC_6093163 | PPAD...)
Affinity DataIC50:  240nMAssay Description:Inhibition of inward ion current elicited by ATP was determined at recombinant P2X3 receptor expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 6(Rattus norvegicus)
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM85043(CAS_149017-66-3 | CHEMBL69234 | NSC_6093163 | PPAD...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of inward ion current elicited by ATP at rat P2X6 receptor (mutant type)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 1(RAT)
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM85043(CAS_149017-66-3 | CHEMBL69234 | NSC_6093163 | PPAD...)
Affinity DataIC50:  99nMAssay Description:Inhibition of inward ion current elicited by ATP at P2X1 receptor expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(RAT)
Max-Planck Institute For Experimental Medicine

Curated by PDSP Ki Database
LigandPNGBDBM85043(CAS_149017-66-3 | CHEMBL69234 | NSC_6093163 | PPAD...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of inward ion current elicited by ATP at rat P2X4 receptor (mutant type)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Max-Planck Institute For Experimental Medicine

Curated by PDSP Ki Database
LigandPNGBDBM85043(CAS_149017-66-3 | CHEMBL69234 | NSC_6093163 | PPAD...)
Affinity DataIC50:  2.75E+4nMAssay Description:Inhibition of inward ion current elicited by ATP at human P2X4 receptor (mutant type)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor(Mus musculus)
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM85043(CAS_149017-66-3 | CHEMBL69234 | NSC_6093163 | PPAD...)
Affinity DataIC50:  2.10E+4nMAssay Description:Inhibition of inward ion current elicited by ATP at mouse P2X4 receptor (mutant type)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 6(Rattus norvegicus)
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM85043(CAS_149017-66-3 | CHEMBL69234 | NSC_6093163 | PPAD...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of inward ion current elicited by ATP at rat P2X6 receptor (wild type)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 1(Mus musculus)
Gwangju Institute Of Science And Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM85043(CAS_149017-66-3 | CHEMBL69234 | NSC_6093163 | PPAD...)
Affinity DataIC50:  99nMAssay Description:Antagonist activity at mouse P2X1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM85043(CAS_149017-66-3 | CHEMBL69234 | NSC_6093163 | PPAD...)
Affinity DataEC50:  240nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 3 (P2X3) at 10 uM,expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 5(Rattus norvegicus)
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM85043(CAS_149017-66-3 | CHEMBL69234 | NSC_6093163 | PPAD...)
Affinity DataEC50:  2.60E+3nMAssay Description:Antagonist activity against recombinant rat P2X purinoceptor 5 (P2X5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 4(Homo sapiens (Human))
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM85043(CAS_149017-66-3 | CHEMBL69234 | NSC_6093163 | PPAD...)
Affinity DataEC50: >1.00E+4nMAssay Description:The compound was evaluated for antagonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 4 (P2Y4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 2(Homo sapiens (Human))
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM85043(CAS_149017-66-3 | CHEMBL69234 | NSC_6093163 | PPAD...)
Affinity DataEC50: >1.00E+4nMAssay Description:Evaluated for agonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 2 (P2Y2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM85043(CAS_149017-66-3 | CHEMBL69234 | NSC_6093163 | PPAD...)
Affinity DataEC50:  6.20E+4nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 7 (P2X7)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 1(RAT)
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM85043(CAS_149017-66-3 | CHEMBL69234 | NSC_6093163 | PPAD...)
Affinity DataEC50:  99nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 1 (P2X1) at 1 uM,expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM85043(CAS_149017-66-3 | CHEMBL69234 | NSC_6093163 | PPAD...)
Affinity DataEC50:  1.70E+3nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 3 (P2X3) at 10 uM, expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Rattus norvegicus)
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM85043(CAS_149017-66-3 | CHEMBL69234 | NSC_6093163 | PPAD...)
Affinity DataEC50: >1.00E+5nMAssay Description:Antagonist activity against phospholipase C coupled rat P2Y purinoceptor 12 (P2Y12)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 2(RAT)
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM85043(CAS_149017-66-3 | CHEMBL69234 | NSC_6093163 | PPAD...)
Affinity DataEC50:  1.20E+4nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat receptor P2X purinoceptor 2 (P2X2) at 30 uM,expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(RAT)
Max-Planck Institute For Experimental Medicine

Curated by PDSP Ki Database
LigandPNGBDBM85043(CAS_149017-66-3 | CHEMBL69234 | NSC_6093163 | PPAD...)
Affinity DataEC50: >1.00E+4nMAssay Description:Antagonist activity against recombinant rat P2X purinoceptor 4 (P2X4) at 3 uM,expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Max-Planck Institute For Experimental Medicine

Curated by PDSP Ki Database
LigandPNGBDBM85043(CAS_149017-66-3 | CHEMBL69234 | NSC_6093163 | PPAD...)
Affinity DataEC50:  1.00E+4nMAssay Description:Antagonist activity against recombinant human P2X purinoceptor 4 (P2X4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 6(Rattus norvegicus)
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM85043(CAS_149017-66-3 | CHEMBL69234 | NSC_6093163 | PPAD...)
Affinity DataEC50: >1.00E+5nMAssay Description:Antagonist activity against recombinant rat P2X purinoceptor 6 (P2X6 )More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Homo sapiens (Human))
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM85043(CAS_149017-66-3 | CHEMBL69234 | NSC_6093163 | PPAD...)
Affinity DataEC50:  1.00E+3nMAssay Description:Evaluated for agonist activity against phospholipase C coupled P2Y purinoceptor 1 (P2Y1) of human erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Gwangju Institute Of Science And Technology (Gist)

Curated by ChEMBL
LigandPNGBDBM85043(CAS_149017-66-3 | CHEMBL69234 | NSC_6093163 | PPAD...)
Affinity DataIC50:  1.18E+3nMAssay Description:Antagonist activity at recombinant human P2X7 receptor assessed as inhibition of BzATP-mediated Yo-Pro uptake measured for 1 hr by FLIPR assayMore data for this Ligand-Target Pair
TargetP2X purinoceptor 3(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM85043(CAS_149017-66-3 | CHEMBL69234 | NSC_6093163 | PPAD...)
Affinity DataIC50:  240nMAssay Description:Antagonist activity at human P2X3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(RAT)
Max-Planck Institute For Experimental Medicine

Curated by PDSP Ki Database
LigandPNGBDBM85043(CAS_149017-66-3 | CHEMBL69234 | NSC_6093163 | PPAD...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of inward ion current elicited by ATP at rat P2X4 receptor (wild type)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Meleagris gallopavo)
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM85043(CAS_149017-66-3 | CHEMBL69234 | NSC_6093163 | PPAD...)
Affinity DataIC50:  1.66E+4nMAssay Description:Inhibition of 10 nM 2-MeSADP-stimulated phospholipase C in turkey erythrocyte membranes using [3H]-inositolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 1(RAT)
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM85043(CAS_149017-66-3 | CHEMBL69234 | NSC_6093163 | PPAD...)
Affinity DataIC50:  9.85E+4nMAssay Description:Compound was tested in a functional ion channel assay of ATP-induced current at recombinant rat P2X1 receptor expressed in Xenopus oocytes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(RAT)
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM85043(CAS_149017-66-3 | CHEMBL69234 | NSC_6093163 | PPAD...)
Affinity DataIC50:  2.40E+5nMAssay Description:Compound was tested in a functional ion channel assay of ATP-induced current at recombinant rat P2X3 receptor expressed in Xenopus oocytes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Homo sapiens (Human))
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM85043(CAS_149017-66-3 | CHEMBL69234 | NSC_6093163 | PPAD...)
Affinity DataEC50:  1.82E+4nMAssay Description:Evaluated for agonist activity against phospholipase C coupled P2Y purinoceptor 1 (P2Y1) of rat erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed