BDBM50209218 4',5,6,7,8-pentamethoxyflavone::5,6,7,8,4'-Pentamethoxyflavone::5,6,7,8-tetramethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one::CHEMBL73930::Tangeretin

SMILES COc1ccc(cc1)-c1cc(=O)c2c(OC)c(OC)c(OC)c(OC)c2o1

InChI Key InChIKey=ULSUXBXHSYSGDT-UHFFFAOYSA-N

Data  2 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50209218   

TargetDelta-type opioid receptor(MOUSE)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50209218(4',5,6,7,8-pentamethoxyflavone | 5,6,7,8,4'-Pentam...)
Affinity DataKi:  7.00E+3nMAssay Description:Displacement of [3H]DPDPE from delta opioid receptor in CD1 mouse whole brain minus cerebellum membranes by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50209218(4',5,6,7,8-pentamethoxyflavone | 5,6,7,8,4'-Pentam...)
Affinity DataKi:  1.63E+4nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in CD1 mouse whole brain minus cerebellum membranes by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50209218(4',5,6,7,8-pentamethoxyflavone | 5,6,7,8,4'-Pentam...)
Affinity DataIC50:  3.90E+4nMAssay Description:Inhibition of MDR1 expressed in MDCK cells using rhodamine 123 staining by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50209218(4',5,6,7,8-pentamethoxyflavone | 5,6,7,8,4'-Pentam...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of xanthine oxidase assessed as decrease in uric acid production by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrease subunit beta(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
Jishou University

Curated by ChEMBL
LigandPNGBDBM50209218(4',5,6,7,8-pentamethoxyflavone | 5,6,7,8,4'-Pentam...)
Affinity DataIC50:  4.63E+6nMAssay Description:Inhibition of Helicobacter pylori ATCC 43504 urease-mediated ammonia production preincubated for 1.5 hrs by indophenol methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50209218(4',5,6,7,8-pentamethoxyflavone | 5,6,7,8,4'-Pentam...)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of BCRP expressed in MCF-7 MX cells using Hoechst 33342 stainingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50209218(4',5,6,7,8-pentamethoxyflavone | 5,6,7,8,4'-Pentam...)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of BCRP expressed in MDCK cells using Hoechst 33342 stainingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed