BDBM50052027 (E)-3-[6-(2,6-Dichloro-phenylsulfanylmethyl)-3-phenethyloxy-pyridin-2-yl]-acrylic acid::CHEMBL90214::SB-209247::Ticolubant

SMILES OC(=O)\C=C\c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccccc1

InChI Key InChIKey=ZJLFOOWTDISDIO-ZRDIBKRKSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50052027   

TargetLeukotriene B4 receptor 1(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052027((E)-3-[6-(2,6-Dichloro-phenylsulfanylmethyl)-3-phe...)
Affinity DataKi:  0.780nMAssay Description:Inhibition of [3H]-LTB4 binding to human neutrophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene B4 receptor 1(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052027((E)-3-[6-(2,6-Dichloro-phenylsulfanylmethyl)-3-phe...)
Affinity DataKi:  0.800nMAssay Description:Compound was tested for binding affinity against human neutrophil LTB4 (leukotriene) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene B4 receptor 1(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052027((E)-3-[6-(2,6-Dichloro-phenylsulfanylmethyl)-3-phe...)
Affinity DataIC50:  1.68E+4nMAssay Description:Inhibitory concentration LTB4 with [3H]-LTD4 in LTD4 receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052027((E)-3-[6-(2,6-Dichloro-phenylsulfanylmethyl)-3-phe...)
Affinity DataIC50:  8.20E+3nMAssay Description:Concentration required to inhibit RBL-1 supernatant 5-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene B4 receptor 1(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052027((E)-3-[6-(2,6-Dichloro-phenylsulfanylmethyl)-3-phe...)
Affinity DataIC50:  3.25E+3nMAssay Description:Inhibitory concentration against LTB4 with [3H]- fMLP in receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed