BDBM50263044 CHEMBL476960::Voglibose

SMILES OCC(CO)N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O

InChI Key InChIKey=FZNCGRZWXLXZSZ-CIQUZCHMSA-N

Data  31 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 31 hits for monomerid = 50263044   

TargetLysosomal alpha-glucosidase(Rattus norvegicus)
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50263044(CHEMBL476960 | Voglibose)
Affinity DataIC50:  120nMAssay Description:Inhibition of Wistar rat intestinal maltase assessed as inhibition of D-glucose release after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMaltase-glucoamylase(Homo sapiens (Human))
Kindai University

Curated by ChEMBL
LigandPNGBDBM50263044(CHEMBL476960 | Voglibose)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of human intestinal maltase using maltose as substrate incubated for 30 mins and immediately heated for 2 mins by glucose oxidase methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50263044(CHEMBL476960 | Voglibose)
Affinity DataIC50:  370nMAssay Description:Inhibition of Wistar rat intestinal sucrase assessed as inhibition of D-glucose release after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50263044(CHEMBL476960 | Voglibose)
Affinity DataIC50:  300nMAssay Description:Inhibition of rat intestinal sucrase using sucrose as substrate incubated for 30 mins by glucose-oxidase methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMaltase-glucoamylase(Homo sapiens (Human))
Kindai University

Curated by ChEMBL
LigandPNGBDBM50263044(CHEMBL476960 | Voglibose)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of human small intestine microsomal maltase using maltose as substrate incubated for 30 mins by glucose-oxidase methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-glucosidase(Rattus norvegicus)
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50263044(CHEMBL476960 | Voglibose)
Affinity DataIC50:  180nMAssay Description:Inhibition of Wistar rat small intestine maltase after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50263044(CHEMBL476960 | Voglibose)
Affinity DataIC50:  5.20E+3nMAssay Description:Inhibition of Wistar rat small intestine isomaltase after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50263044(CHEMBL476960 | Voglibose)
Affinity DataIC50:  370nMAssay Description:Inhibition of Wistar rat small intestine sucrase after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-glucosidase(Rattus norvegicus)
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50263044(CHEMBL476960 | Voglibose)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of rat small intestinal maltase after 30 mins by glucose-oxidase methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50263044(CHEMBL476960 | Voglibose)
Affinity DataIC50:  200nMAssay Description:Inhibition of rat small intestinal sucrase after 30 mins by glucose-oxidase methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50263044(CHEMBL476960 | Voglibose)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of rat small intestinal isomaltase after 30 mins by glucose-oxidase methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50263044(CHEMBL476960 | Voglibose)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of rat small intestinal isomaltase after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-glucosidase(Rattus norvegicus)
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50263044(CHEMBL476960 | Voglibose)
Affinity DataIC50:  200nMAssay Description:Inhibition of rat small intestinal maltase after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50263044(CHEMBL476960 | Voglibose)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of rat small intestinal sucrase after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-glucosidase(Rattus norvegicus)
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50263044(CHEMBL476960 | Voglibose)
Affinity DataIC50:  110nMAssay Description:Inhibition of rat intestinal brush border membrane maltaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50263044(CHEMBL476960 | Voglibose)
Affinity DataIC50:  160nMAssay Description:Inhibition of rat intestinal brush border membrane isomaltaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50263044(CHEMBL476960 | Voglibose)
Affinity DataIC50:  70nMAssay Description:Inhibition of rat intestinal brush border membrane sucraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50263044(CHEMBL476960 | Voglibose)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of human lysosomal alpha-glucosidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen debranching enzyme(Oryctolagus cuniculus)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50263044(CHEMBL476960 | Voglibose)
Affinity DataIC50:  7.00E+4nMAssay Description:Inhibition of rabbit muscle amylo-1,6-glucosidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50263044(CHEMBL476960 | Voglibose)
Affinity DataIC50:  70nMAssay Description:Inhibition of maltase in human Caco-2 cell model system after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50263044(CHEMBL476960 | Voglibose)
Affinity DataIC50:  370nMAssay Description:Inhibition of rat intestinal sucrase using sucrose as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50263044(CHEMBL476960 | Voglibose)
Affinity DataIC50:  5.20E+3nMAssay Description:Inhibition of rat intestinal isomaltase using isomoltose as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-glucosidase(Rattus norvegicus)
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50263044(CHEMBL476960 | Voglibose)
Affinity DataIC50:  120nMAssay Description:Inhibition of rat intestinal maltase using moltose as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50263044(CHEMBL476960 | Voglibose)
Affinity DataIC50:  200nMAssay Description:Inhibition of rat intestinal sucraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50263044(CHEMBL476960 | Voglibose)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of rat intestinal isomaltaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-glucosidase(Rattus norvegicus)
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50263044(CHEMBL476960 | Voglibose)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of rat intestinal maltaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50263044(CHEMBL476960 | Voglibose)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50263044(CHEMBL476960 | Voglibose)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50263044(CHEMBL476960 | Voglibose)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50263044(CHEMBL476960 | Voglibose)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSucrase-isomaltase, intestinal(Rattus norvegicus (Rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50263044(CHEMBL476960 | Voglibose)
Affinity DataIC50:  5.20E+3nMAssay Description:Inhibition of Wistar rat intestinal isomaltase assessed as inhibition of D-glucose release after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed