BDBM50038879 (S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidine-1-carboxylic acid benzyl ester::CHEMBL79993::JTP-4819::Z-PRO-PROLINAL
SMILES O=C[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)OCc1ccccc1
InChI Key InChIKey=ORZXYSPOAVJYRU-HOTGVXAUSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 15 hits for monomerid = 50038879
Affinity DataKi: 0.210nMAssay Description:Inhibition of bovine brain POPMore data for this Ligand-Target Pair
Affinity DataKi: 0.350nMAssay Description:Inhibition of POP in bovine serum using Z-Gly-Pro-NH-Mec fluorimetric substrateMore data for this Ligand-Target Pair
Affinity DataKi: 0.350nMAssay Description:Inhibition of mouse brain POPMore data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Inhibition of recombinant human POP assessed as affinity constant of second step of inhibition pre-incubated for 2 hrs before addition of ZGP-pNA sub...More data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Inhibition of Flavobacterium meningosepticum POPMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Inhibition of recombinant human POP pre-incubated for 30 mins before addition of ZGP-pNA substrate by absorbance assayMore data for this Ligand-Target Pair
Affinity DataKi: 4.30nMAssay Description:Inhibition of prolyl oligopeptidaseMore data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Inhibition of recombinant human POP assessed as affinity constant of first step of the binding event pre-incubated for 2 hrs before addition of ZGP-p...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:In vitro inhibitory activity against purified prolyl endopeptidase (PEP) from canine brain.More data for this Ligand-Target Pair
TargetChymotrypsin-like elastase family member 1(Homo sapiens (Human))
Kyungpook National University
Curated by ChEMBL
Kyungpook National University
Curated by ChEMBL
Affinity DataIC50: 51.6nMAssay Description:Inhibition of Flavobacterium meningosepticum PEPMore data for this Ligand-Target Pair
Affinity DataIC50: 1.27nMAssay Description:Inhibition of Flavobacterium meningosepticum propyl endopeptidaseMore data for this Ligand-Target Pair
Affinity DataIC50: 2.80nMAssay Description:Inhibition of POP (unknown origin) using (Z)-Gly-Pro-p-nitroanilide as substrate preincubated for 5 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.330nMAssay Description:In vitro inhibitory activity of the compound against prolyl oligopeptidase (POP) from pigbrain expressedMore data for this Ligand-Target Pair
Affinity DataIC50: 54nMAssay Description:Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
Affinity DataIC50: 0.330nMpH: 7.0Assay Description:In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 deg...More data for this Ligand-Target Pair