BindingDB logo
myBDB logout

A caveat regarding protein Target sequences

Literature curators typically retrieve protein sequences from a database, such as UniProtKB, and it can happen that the protein sequence used in the experimental binding study is not be a perfect match to that drawn from the sequence database and entered into BindingDB or one of our source databases, such as ChEMBL. There may also be cases where the protein is known to contain amino acid substitutions relative to the wild-type, but this information does not make its way into the stored sequence. Additional variations also may occur, such as a His tag left over from purification, or a post-translational modification. For these reasons, if you need to be sure of the sequence of the protein Target in a BindingDB assay, you are strongly advised to consult the source publication. If you do find a possible error, let us know and we will review the entry and correct it if necessary.