BDBM100750 CHEMBL2397003::US8507714, 239

SMILES CC[C@@H](NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)C(=O)Nc1nnn[nH]1

InChI Key InChIKey=BKBRIRMQOJEQGE-GLGOKHISSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 100750   

TargetChymase(Homo sapiens (Human))
Daiichi Sankyo

US Patent
LigandPNGBDBM100750(CHEMBL2397003 | US8507714, 239)
Affinity DataIC50:  260nMAssay Description:Inhibitory activity of the compounds for recombinant human chymase was measured by method of Pasztor et al. (Pasztor et al., Acta Biol. Hung. 42:285-...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetChymase(Homo sapiens (Human))
Daiichi Sankyo

US Patent
LigandPNGBDBM100750(CHEMBL2397003 | US8507714, 239)
Affinity DataIC50:  260nMAssay Description:Inhibition of human recombinant chymase using Suc-Ala-Ala-Pro-Phe-MCA as substrate assessed as AMC formation preincubated for 10 mins followed by sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin G(Homo sapiens (Human))
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM100750(CHEMBL2397003 | US8507714, 239)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human neutrophil cathepsin G using Boc-Gln-Ala-Arg-MCA as substrate preincubated for 10 mins followed by substrate addition measured af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM100750(CHEMBL2397003 | US8507714, 239)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human neutrophil elastase using MeOSuc-Ala-Ala-Pro-Val-pNA as substrate preincubated for 10 mins followed by substrate addition measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed