BDBM104020 MK181

SMILES OC(=O)COc1cc(Cl)ccc1C(=O)NCc1ccc(Br)cc1

InChI Key InChIKey=PAOIFRPAIJVWIK-UHFFFAOYSA-N

Data  6 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 104020   

TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

LigandPNGBDBM104020(MK181)
Affinity DataIC50:  710nMpH: 7.0 T: 2°CAssay Description:The assays were performed at 25 degrees Celsius in a 100mM sodium phosphate buffer (pH 7.0), with the AR protein amount reaching the Vmax and 0.2mM N...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

LigandPNGBDBM104020(MK181)
Affinity DataIC50:  710nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

LigandPNGBDBM104020(MK181)
Affinity DataIC50:  550nMAssay Description:Inhibition of human ALR2More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B10(Homo sapiens (Human))
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire

LigandPNGBDBM104020(MK181)
Affinity DataIC50:  3.70E+3nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B10 [K125R,V301L](Homo sapiens (Human))
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire

LigandPNGBDBM104020(MK181)
Affinity DataIC50:  1.02E+4nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B10(Homo sapiens (Human))
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire

LigandPNGBDBM104020(MK181)
Affinity DataIC50:  4.50E+3nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair