BDBM10592 7-chloro-15-methyl-10-azatetracyclo[11.3.1.0^{2,11}.0^{4,9}]heptadeca-2,4(9),5,7,10,14-hexaen-3-amine::CHEMBL140476::Huprine Y.HCl::US9238626, (+/-)-Huprine Y HCl
SMILES CC1=CC2CC(C1)c1c(C2)nc2cc(Cl)ccc2c1N
InChI Key InChIKey=UKCBMHDZLYYTMI-UHFFFAOYSA-N
Data 43 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 43 hits for monomerid = 10592
Affinity DataIC50: 0.780nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
Affinity DataIC50: 181nMAssay Description:Inhibition of human serum BChE using butyrylthiocholine iodide as a substrate preincubated for 20 mins followed by substrate addition by spectrophoto...More data for this Ligand-Target Pair
Affinity DataIC50: 0.690nMpH: 8.0 T: 2°CAssay Description:AChE inhibitory activity of compounds (Ia)-(Ie) and (-)-(Ib) and
(+)-(Ib) was evaluated spectrophotometrically at 25° C. by the
method of Ellma...More data for this Ligand-Target Pair
Affinity DataIC50: 181nMpH: 8.0 T: 2°CAssay Description:BChE inhibitory activity determinations were carried out similarly by
the method of Ellman et al., using 0.02 unit/mL of human serum BChE and
300 u...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Universitat De Barcelona
US Patent
Universitat De Barcelona
US Patent
Affinity DataIC50: 0.0800nMpH: 8.0 T: 2°CAssay Description:AChE inhibitory activity of compounds (Ia)-(Ie) and (-)-(Ib) and
(+)-(Ib) was evaluated spectrophotometrically at 25° C. by the
method of Ellma...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 181nMAssay Description:Inhibition of human serum BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 175nMAssay Description:Inhibition of human serum BChE using butyrylthiocholine iodide preincubated for 20 mins before substrate addition by Ellman methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins before substrate addition by Ellman methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.610nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins by Ellman methodMore data for this Ligand-Target Pair
Affinity DataIC50: 3.10nMAssay Description:Compound was evaluated for the inhibition of acetylcholinesterase activity from bovine erythrocytes after 0 minutes of incubationMore data for this Ligand-Target Pair
Affinity DataIC50: 247nMAssay Description:Inhibition of butyrylcholinesterase (BChE) in human serumMore data for this Ligand-Target Pair
Affinity DataIC50: 3.03nMAssay Description:Compound was evaluated for the inhibition of acetylcholinesterase activity from bovine erythrocytes after 0 minutes of incubationMore data for this Ligand-Target Pair
Affinity DataIC50: 4.23nMAssay Description:Compound was evaluated for the inhibition of acetylcholinesterase of bovine erythrocytesMore data for this Ligand-Target Pair
Affinity DataIC50: 0.320nMAssay Description:Inhibition of acetylcholinesterase isolated from Human erythrocytes.More data for this Ligand-Target Pair
Affinity DataIC50: 0.640nMAssay Description:Compound was evaluated for the inhibition of acetylcholinesterase activity from bovine erythrocytes after 30 minutes of incubationMore data for this Ligand-Target Pair
Affinity DataIC50: 1.15nMAssay Description:Compound was evaluated for the inhibition of acetylcholinesterase of bovine erythrocytesMore data for this Ligand-Target Pair
Affinity DataIC50: 247nMAssay Description:Inhibition of butyrylcholinesterase (BChE) in human serumMore data for this Ligand-Target Pair
Affinity DataIC50: 0.640nMAssay Description:Compound was evaluated for the inhibition of acetylcholinesterase activity from bovine erythrocytes after 30 minutes of incubationMore data for this Ligand-Target Pair
Affinity DataIC50: 0.780nMAssay Description:Inhibition of acetylcholinesterase isolated from Human erythrocytes.More data for this Ligand-Target Pair
Affinity DataIC50: 236nMAssay Description:Inhibition of butyrylcholinesterase (BChE) in human serumMore data for this Ligand-Target Pair
Affinity DataIC50: 4.23nMAssay Description:Compound was evaluated for the inhibition of acetylcholinesterase of bovine erythrocytesMore data for this Ligand-Target Pair
Affinity DataIC50: 0.780nMAssay Description:Inhibition of acetylcholinesterase isolated from Human erythrocytes.More data for this Ligand-Target Pair
Affinity DataIC50: 4.23nMAssay Description:Inhibition of bovine erythrocyte AChEMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:In vitro inhibitory activity against bovine acetylcholinesteraseMore data for this Ligand-Target Pair
Affinity DataIC50: 0.320nMAssay Description:Inhibitory activity against human erythrocyte acetylcholinesteraseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.84nMAssay Description:Inhibition of human recombinant AChE in erythrocytes by Ellman's assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.20nMAssay Description:Inhibition of bovine erythrocyte acetylcholinesterase using acetylthiocholine as substrate incubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 247nMAssay Description:Inhibition of human serum butyrylcholinesterase using butyrylthiocholine iodide as substrate incubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 4.23nMAssay Description:Inhibition of bovine erythrocyte acetylcholinesterase using acetylthiocholine as substrate incubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.780nMAssay Description:Inhibition of human Acetylcholinesterase using acetylthiocholine as substrate incubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.780nMAssay Description:Inhibition of human Acetylcholinesterase using acetylthiocholine as substrate incubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 123nMAssay Description:Inhibition of human Acetylcholinesterase using acetylthiocholine as substrate incubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 36.1nMAssay Description:Inhibition of bovine erythrocyte acetylcholinesterase using acetylthiocholine as substrate incubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 236nMAssay Description:Inhibition of human serum butyrylcholinesterase using butyrylthiocholine iodide as substrate incubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 236nMAssay Description:Inhibition of human serum butyrylcholinesterase using butyrylthiocholine iodide as substrate incubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of recombinant human AChE using acetylthiocholineiodide as substrate preincubated for 20 mins followed by substrate addition by Ellman's m...More data for this Ligand-Target Pair
Affinity DataIC50: 181nMAssay Description:Inhibition of human serum BChE using butyrylthiocholineiodide as substrate preincubated for 20 mins followed by substrate addition by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Inhibition of recombinant human AChE using acetylthiocholine as substrate by DTNB-reagent based Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 358nMAssay Description:Inhibition of recombinant human BuChE using butyrylthiocholine as substrate by Ellman's methodMore data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Homo sapiens (Human))
University Hospital Hradec Kralove
Curated by ChEMBL
University Hospital Hradec Kralove
Curated by ChEMBL
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of recombinant human nNOSMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as a substrate preincubated for 20 mins followed by substrate addition by spectro...More data for this Ligand-Target Pair
Affinity DataIC50: 236nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair