BDBM106736 CHEMBL1823365::US8586620, 138

SMILES CN1CCC[C@@H]1CCn1ccc2ccc(cc12)N=C(N)c1cccs1

InChI Key InChIKey=ZPYXFXHKINDFBM-QGZVFWFLSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 106736   

TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

US Patent
LigandPNGBDBM106736(CHEMBL1823365 | US8586620, 138)
Affinity DataIC50:  320nMAssay Description:Enzyme assay using recombinant human inducible NOS (iNOS), human endothelial constitutive NOS (eNOS) or human neuronal constitutive NOS (nNOS).More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Neuraxon

US Patent
LigandPNGBDBM106736(CHEMBL1823365 | US8586620, 138)
Affinity DataIC50:  1.60E+4nMAssay Description:Enzyme assay using recombinant human inducible NOS (iNOS), human endothelial constitutive NOS (eNOS) or human neuronal constitutive NOS (nNOS).More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

US Patent
LigandPNGBDBM106736(CHEMBL1823365 | US8586620, 138)
Affinity DataIC50:  320nMAssay Description:Inhibition of recombinant human nNOS expressed in baculovirus infected insect Sf9 cells assessed as conversion of [3H]-L-arginine into [3H]-L-citrull...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM106736(CHEMBL1823365 | US8586620, 138)
Affinity DataIC50:  7.20E+4nMAssay Description:Inhibition of human recombinant iNOS expressed in Sf9 cells assessed as inhibition of conversion of [3H]-L-arginine to [3H]-L-citrulline after 45 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Neuraxon

Curated by ChEMBL
LigandPNGBDBM106736(CHEMBL1823365 | US8586620, 138)
Affinity DataIC50:  7.20E+4nMAssay Description:Inhibition of recombinant human iNOS expressed in baculovirus infected insect Sf9 cells assessed as conversion of [3H]-L-arginine into [3H]-L-citrull...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Neuraxon

US Patent
LigandPNGBDBM106736(CHEMBL1823365 | US8586620, 138)
Affinity DataIC50:  320nMAssay Description:Inhibition of human recombinant nNOS expressed in Sf9 cells assessed as inhibition of conversion of [3H]-L-arginine to [3H]-L-citrulline after 45 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Neuraxon

US Patent
LigandPNGBDBM106736(CHEMBL1823365 | US8586620, 138)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of human recombinant eNOS expressed in Sf9 cells assessed as inhibition of conversion of [3H]-L-arginine to [3H]-L-citrulline after 45 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Neuraxon

US Patent
LigandPNGBDBM106736(CHEMBL1823365 | US8586620, 138)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of recombinant human eNOS expressed in baculovirus infected insect Sf9 cells assessed as conversion of [3H]-L-arginine into [3H]-L-citrull...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed