BDBM106788 3‐(3‐methylphenyl)‐3,4‐dihydro‐2H‐1‐benzopyran‐7,8‐ diol::7,8-Dihydroxy-3′-methylisoflavan (5c)::HIR-309

SMILES Cc1cccc(c1)C1COc2c(C1)ccc(O)c2O

InChI Key InChIKey=PHLLTOYGGHVCAQ-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 106788   

TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Homo sapiens (Human))
Universidad De Santiago De Chile

LigandPNGBDBM106788(3‐(3‐methylphenyl)‐3,4‐dih...)
Affinity DataIC50:  6.40E+3nMpH: 8.0 T: 2°CAssay Description:All reactions were carried in a volume of 2 mL stirred at 23°C with approximately 2.040 Units of 12-hLOX, 4.200 Units of 15-hLOX-1, and 6.600 Un...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
Universidad De Santiago De Chile

LigandPNGBDBM106788(3‐(3‐methylphenyl)‐3,4‐dih...)
Affinity DataIC50:  5.80E+3nMpH: 7.5 T: 2°CAssay Description:All reactions were carried in a volume of 2 mL stirred at 23°C with approximately 2.040 Units of 12-hLOX, 4.200 Units of 15-hLOX-1, and 6.600 Un...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Homo sapiens (Human))
Universidad De Santiago De Chile

LigandPNGBDBM106788(3‐(3‐methylphenyl)‐3,4‐dih...)
Affinity DataIC50:  3.30E+4nMpH: 7.5 T: 2°CAssay Description:All reactions were carried in a volume of 2 mL stirred at 23°C with approximately 2.040 Units of 12-hLOX, 4.200 Units of 15-hLOX-1, and 6.600 Un...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Universidad De Santiago

LigandPNGBDBM106788(3‐(3‐methylphenyl)‐3,4‐dih...)
Affinity DataIC50: >1.50E+5nMpH: 8.0Assay Description:Approximately 2 µg of either COX-1 or COX-2 was added to buffer containing 100 µM AA, 0.1 M Tris-HCl buffer (pH 8.0), 5 mM EDTA, 2 mM phenol, and 1 µ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Universidad De Santiago

LigandPNGBDBM106788(3‐(3‐methylphenyl)‐3,4‐dih...)
Affinity DataIC50:  150nMpH: 7.3 T: 2°CAssay Description:The reactions were done in a volume of 2 mL and constantly stirred using a magnetic stir bar at room temperature (23 °C). Reactions with the crude, a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Universidad De Santiago

LigandPNGBDBM106788(3‐(3‐methylphenyl)‐3,4‐dih...)
Affinity DataIC50: >1.50E+5nMpH: 8.0Assay Description:Approximately 2 µg of either COX-1 or COX-2 was added to buffer containing 100 µM AA, 0.1 M Tris-HCl buffer (pH 8.0), 5 mM EDTA, 2 mM phenol, and 1 µ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Homo sapiens (Human))
Universidad De Santiago De Chile

LigandPNGBDBM106788(3‐(3‐methylphenyl)‐3,4‐dih...)
Affinity DataIC50:  3.30E+4nMpH: 7.3 T: 2°CAssay Description:The reactions were done in a volume of 2 mL and constantly stirred using a magnetic stir bar at room temperature (23 °C). Reactions with the crude, a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed