BDBM108218 5-(hydroxymethyl)-2-octyl-5H,6H,7H,8H-imidazo[1,2- a]pyridine-6,7,8-triol (Compound 4)

SMILES CCCCCCCCc1cn2C(CO)C(O)C(O)C(O)c2n1

InChI Key InChIKey=OMVDIWMZQBJVFN-UHFFFAOYSA-N

Data  1 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 108218   

TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Nankai University

LigandPNGBDBM108218(5-(hydroxymethyl)-2-octyl-5H,6H,7H,8H-imidazo[1,2-...)
Affinity DataKi:  5.38nMpH: 5.2Assay Description:To determine inhibition constant (Ki), substrate (7.5µL, various concentrations in Mcllvaine buffer, pH 5.2) and enzyme (12.5µL, 0.1mg/mL) ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Nankai University

LigandPNGBDBM108218(5-(hydroxymethyl)-2-octyl-5H,6H,7H,8H-imidazo[1,2-...)
Affinity DataIC50:  8.39nMpH: 5.2Assay Description:The assays were performed at 37°C with 4-MU-β-ᴅ-Glu as the substrate in Mcllvaine buffer (sodium citrate (100mM) and sodium phosphate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-galactosidase(Coffea arabica (Coffee beans))
Nankai University

LigandPNGBDBM108218(5-(hydroxymethyl)-2-octyl-5H,6H,7H,8H-imidazo[1,2-...)
Affinity DataIC50:  1.25E+4nMpH: 10.6 T: 2°CAssay Description:In a 96-well plates, 10µL of commercial enzyme solutions without (control) or with 20µL of inhibitor were incubated at 37°C for 5 min....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOligo-1,6-glucosidase IMA1(Saccharomyces cerevisiae S288c (Baker's yeast))
Nankai University

LigandPNGBDBM108218(5-(hydroxymethyl)-2-octyl-5H,6H,7H,8H-imidazo[1,2-...)
Affinity DataIC50:  970nMpH: 10.6 T: 2°CAssay Description:In a 96-well plates, 10µL of commercial enzyme solutions without (control) or with 20µL of inhibitor were incubated at 37°C for 5 min....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-galactosidase(Bos taurus (Bovine))
Nankai University

LigandPNGBDBM108218(5-(hydroxymethyl)-2-octyl-5H,6H,7H,8H-imidazo[1,2-...)
Affinity DataIC50:  37nMpH: 10.6 T: 2°CAssay Description:In a 96-well plates, 10µL of commercial enzyme solutions without (control) or with 20µL of inhibitor were incubated at 37°C for 5 min....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Nankai University

LigandPNGBDBM108218(5-(hydroxymethyl)-2-octyl-5H,6H,7H,8H-imidazo[1,2-...)
Affinity DataIC50:  5.05nMpH: 7.0Assay Description:The assays were performed at 37°C with 4-MU-β-ᴅ-Glu as the substrate in Mcllvaine buffer (sodium citrate (100mM) and sodium phosphate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPrunasin hydrolase(Prunus dulcis (Almond))
Nankai University

LigandPNGBDBM108218(5-(hydroxymethyl)-2-octyl-5H,6H,7H,8H-imidazo[1,2-...)
Affinity DataIC50:  117nMpH: 10.6 T: 2°CAssay Description:In a 96-well plates, 10µL of commercial enzyme solutions without (control) or with 20µL of inhibitor were incubated at 37°C for 5 min....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed