BDBM10844 4-(1H-indol-3-yl)pyrimidin-2-amine::Meridianin G

SMILES Nc1nccc(n1)-c1c[nH]c2ccccc12

InChI Key InChIKey=QNMZWFNNJMGJPU-UHFFFAOYSA-N

Data  12 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 10844   

LigandPNGBDBM10844(4-(1H-indol-3-yl)pyrimidin-2-amine | Meridianin G)
Affinity DataIC50:  1.50E+5nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30°C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Cnrs

LigandPNGBDBM10844(4-(1H-indol-3-yl)pyrimidin-2-amine | Meridianin G)
Affinity DataIC50:  1.40E+5nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30°C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM10844(4-(1H-indol-3-yl)pyrimidin-2-amine | Meridianin G)
Affinity DataIC50:  1.20E+5nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30°C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent protein kinase 1(Bos taurus (bovine))
Cnrs

LigandPNGBDBM10844(4-(1H-indol-3-yl)pyrimidin-2-amine | Meridianin G)
Affinity DataIC50:  4.00E+5nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30°C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Cnrs

LigandPNGBDBM10844(4-(1H-indol-3-yl)pyrimidin-2-amine | Meridianin G)
Affinity DataIC50:  3.50E+5nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30°C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM10844(4-(1H-indol-3-yl)pyrimidin-2-amine | Meridianin G)
Affinity DataIC50:  588nMAssay Description:Inhibition of full-length recombinant human GST-tagged Dyrk1a expressed in baculovirus expression system using Alexa-Fluor tracer-236 incubated for 6...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Clermont Universite£

Curated by ChEMBL
LigandPNGBDBM10844(4-(1H-indol-3-yl)pyrimidin-2-amine | Meridianin G)
Affinity DataIC50:  530nMAssay Description:Inhibition of human recombinant GST-tagged CLK1 using GRSRSRSRSRSR as substrateMore data for this Ligand-Target Pair
LigandPNGBDBM10844(4-(1H-indol-3-yl)pyrimidin-2-amine | Meridianin G)
Affinity DataIC50:  700nMAssay Description:Inhibition of rat recombinant GST-tagged DYRK1A using myelin protein as substrate and [gamma32]-ATP after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Clermont Universite£

Curated by ChEMBL
LigandPNGBDBM10844(4-(1H-indol-3-yl)pyrimidin-2-amine | Meridianin G)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of human recombinant CDK5/p25 using Histone H1 and [gamma32]-ATP after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM10844(4-(1H-indol-3-yl)pyrimidin-2-amine | Meridianin G)
Affinity DataIC50:  4.10E+4nMAssay Description:Inhibition of NIK (unknown origin) autophosphorylation after 1 hr by chemiluminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM10844(4-(1H-indol-3-yl)pyrimidin-2-amine | Meridianin G)
Affinity DataIC50:  1.48E+4nMAssay Description:Inhibition of full-length recombinant human His-tagged GSK3B recombinant in baculovirus expression system using Alexa-Fluor tracer-236 incubated for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM10844(4-(1H-indol-3-yl)pyrimidin-2-amine | Meridianin G)
Affinity DataIC50:  3.50E+5nMAssay Description:Inhibition of human GSK3betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed