BDBM10951 (2S,6R)-3-methyl-8-oxa-3-azatricyclo[7.4.0.0^{2,6}]trideca-1(13),9,11-trien-10-yl N-methylcarbamate::Conformationally Restricted Rivastigmine Analogue 3

SMILES [H][C@@]12CCN(C)[C@]1([H])c1cccc(OC(=O)NC)c1OC2

InChI Key InChIKey=UKFCIGJAJAIROZ-CABZTGNLSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 10951   

TargetAcetylcholinesterase(Homo sapiens (Human))
University Of Bologna

LigandPNGBDBM10951((2S,6R)-3-methyl-8-oxa-3-azatricyclo[7.4.0.0^{2,6}...)
Affinity DataIC50:  30nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
University Of Bologna

LigandPNGBDBM10951((2S,6R)-3-methyl-8-oxa-3-azatricyclo[7.4.0.0^{2,6}...)
Affinity DataIC50:  59.4nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
University Of Bologna

LigandPNGBDBM10951((2S,6R)-3-methyl-8-oxa-3-azatricyclo[7.4.0.0^{2,6}...)
Affinity DataIC50:  74.1nMAssay Description:Inhibitory activity against acetylcholinesterase in human erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
University Of Bologna

LigandPNGBDBM10951((2S,6R)-3-methyl-8-oxa-3-azatricyclo[7.4.0.0^{2,6}...)
Affinity DataIC50:  74.1nMAssay Description:Inhibitory activity against acetylcholinesterase in human erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
University Of Bologna

LigandPNGBDBM10951((2S,6R)-3-methyl-8-oxa-3-azatricyclo[7.4.0.0^{2,6}...)
Affinity DataIC50:  74.1nMAssay Description:Inhibitory activity against acetylcholinesterase in human erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
University Of Bologna

LigandPNGBDBM10951((2S,6R)-3-methyl-8-oxa-3-azatricyclo[7.4.0.0^{2,6}...)
Affinity DataIC50:  54nMAssay Description:Inhibitory activity against butyrylcholinesterase (BChE) in human erythrocyteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
University Of Bologna

LigandPNGBDBM10951((2S,6R)-3-methyl-8-oxa-3-azatricyclo[7.4.0.0^{2,6}...)
Affinity DataIC50:  54nMAssay Description:Inhibitory activity against butyrylcholinesterase (BChE) in human erythrocyteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
University Of Bologna

LigandPNGBDBM10951((2S,6R)-3-methyl-8-oxa-3-azatricyclo[7.4.0.0^{2,6}...)
Affinity DataIC50:  54nMAssay Description:Inhibitory activity against butyrylcholinesterase (BChE) in human erythrocyteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed