BDBM110706 US8614206, 139

SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1N1CC[C@@H](N)[C@H](F)CC1

InChI Key InChIKey=NHXVGMQFCYBLTL-ZWNOBZJWSA-N

Data  5 KI  9 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 110706   

TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM110706(US8614206, 139)
Affinity DataKi:  0.0200nMAssay Description:Inhibition of recombinant human PIM3 using FAM-pimtide as substrate after 90 mins by Z-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM110706(US8614206, 139)
Affinity DataKi:  0.0300nMAssay Description:Inhibition of recombinant human PIM1 using FAM-pimtide as substrate after 90 mins by Z-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM110706(US8614206, 139)
Affinity DataKi:  0.0400nMpH: 7.2Assay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM110706(US8614206, 139)
Affinity DataKi:  0.100nMAssay Description:Inhibition of recombinant human PIM2 using FAM-pimtide as substrate after 90 mins by Z-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM110706(US8614206, 139)
Affinity DataKi:  1.12E+3nMAssay Description:Time dependent inhibition of CYP3A4 (unknown origin) using testosterone as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM110706(US8614206, 139)
Affinity DataIC50:  2.50E+3nMAssay Description:Agonist activity at 5HT1A receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM110706(US8614206, 139)
Affinity DataIC50:  2.30E+4nMAssay Description:Inhibition of GSK3beta in human human MM1S cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM110706(US8614206, 139)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of human ERG expressed in HEK293 cells after 5 mins by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM110706(US8614206, 139)
Affinity DataIC50:  500nMAssay Description:Inhibition of dopamine receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM110706(US8614206, 139)
Affinity DataIC50:  7.50E+3nMAssay Description:Reversible inhibition of CYP3A4 (unknown origin) using midazolam as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM110706(US8614206, 139)
Affinity DataIC50:  6.30E+3nMAssay Description:Reversible inhibition of CYP3A4 (unknown origin) using testosterone as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM110706(US8614206, 139)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibition of MAP4K4 (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM110706(US8614206, 139)
Affinity DataIC50:  4.90E+3nMAssay Description:Antagonist activity at 5HT1A receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM110706(US8614206, 139)
Affinity DataIC50:  2.50E+3nMAssay Description:Antagonist activity at alpha 1a adrenergic receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed