BDBM112616 US8618103, I-112

SMILES C[C@H]1C[C@@H](CN(C1)S(=O)(=O)CC#N)Nc1nc(ncc1-c1cnc2[nH]ccc2n1)N1CCN(C)CC1

InChI Key InChIKey=QHRMQKJISSPTFZ-IRXDYDNUSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 112616   

TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM112616(US8618103, I-112)
Affinity DataKi:  0.00207nM IC50:  0.00415nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM112616(US8618103, I-112)
Affinity DataIC50:  0.0782nMpH: 7.2Assay Description:The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP. More data for this Ligand-Target Pair
In DepthDetails US Patent