BDBM11868 CHEMBL256157::N-Hydroxy-4-{[(4-phenoxyphenyl)sulfonyl]methyl}-1-prop-2-ynylpiperidine-4-carboxamide Hydrochloride::N-hydroxy-4-{[(4-phenoxybenzene)sulfonyl]methyl}-1-(prop-2-yn-1-yl)piperidine-4-carboxamide hydrochloride::beta-sulfone 7e

SMILES ONC(=O)C1(CS(=O)(=O)c2ccc(Oc3ccccc3)cc2)CCN(CC#C)CC1

InChI Key InChIKey=PRJCFROAJDAXAD-UHFFFAOYSA-N

Data  6 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 11868   

Target72 kDa type IV collagenase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM11868(CHEMBL256157 | N-Hydroxy-4-{[(4-phenoxyphenyl)sulf...)
Affinity DataKi:  0.25nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM11868(CHEMBL256157 | N-Hydroxy-4-{[(4-phenoxyphenyl)sulf...)
Affinity DataKi:  0.550nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM11868(CHEMBL256157 | N-Hydroxy-4-{[(4-phenoxyphenyl)sulf...)
Affinity DataKi:  0.600nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Pfizer

LigandPNGBDBM11868(CHEMBL256157 | N-Hydroxy-4-{[(4-phenoxyphenyl)sulf...)
Affinity DataKi:  4.5nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM11868(CHEMBL256157 | N-Hydroxy-4-{[(4-phenoxyphenyl)sulf...)
Affinity DataKi:  35nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM11868(CHEMBL256157 | N-Hydroxy-4-{[(4-phenoxyphenyl)sulf...)
Affinity DataKi:  417nM ΔG°:  -8.70kcal/molepH: 7.5 T: 2°CAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM11868(CHEMBL256157 | N-Hydroxy-4-{[(4-phenoxyphenyl)sulf...)
Affinity DataIC50:  8.66E+3nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM11868(CHEMBL256157 | N-Hydroxy-4-{[(4-phenoxyphenyl)sulf...)
Affinity DataIC50: <1.5nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM11868(CHEMBL256157 | N-Hydroxy-4-{[(4-phenoxyphenyl)sulf...)
Affinity DataIC50: <1.5nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Pfizer

LigandPNGBDBM11868(CHEMBL256157 | N-Hydroxy-4-{[(4-phenoxyphenyl)sulf...)
Affinity DataIC50: <1.5nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed