BDBM123510 US8748435, 35

SMILES CCc1nn2c(C)cc(C)nc2c1Cc1ccc(cc1)-c1nnc(o1)C1CCNCC1

InChI Key InChIKey=HXPQWNPLNIEJOW-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 123510   

TargetG-protein coupled receptor 4(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM123510(US8748435, 35)
Affinity DataIC50:  74nMpH: 8.0Assay Description:Serial dilutions of compounds (stock in 10 mM DMSO) are prepared by first diluting the compounds in DMSO followed by a 1:50 dilution into assay buffe...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetG-protein coupled receptor 4(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM123510(US8748435, 35)
Affinity DataIC50:  70nMAssay Description:Antagonist activity at human GPR4 expressed in human HeLa cells assessed as inhibition of IBMX-induced cAMP accumulation after 15 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM123510(US8748435, 35)
Affinity DataIC50: >3.00E+4nMAssay Description:Displacement of [3H]-R(-)-alpha-Methyl[imidazole-2.5(n)]histamine from human recombinant histamine H3 receptor expressed in CHOK1 cell membranes afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled receptor 4(Mus musculus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM123510(US8748435, 35)
Affinity DataIC50:  530nMAssay Description:Antagonist activity at mouse GPR4 expressed in HEK cells assessed as inhibition of IBMX-induced cAMP accumulation after 15 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM123510(US8748435, 35)
Affinity DataIC50:  1.90E+4nMAssay Description:Displacement of [3H]dofetilide from recombinant human ERG expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPsychosine receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM123510(US8748435, 35)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of TDAG8 (unknown origin) expressed in human HeLa cells assessed as reduction in cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOvarian cancer G-protein coupled receptor 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM123510(US8748435, 35)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of OGR1 (unknown origin) expressed in human HeLa cells assessed as reduction in cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled receptor 4(Rattus norvegicus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM123510(US8748435, 35)
Affinity DataIC50:  1.84E+3nMAssay Description:Antagonist activity at rat GPR4 expressed in HEK cells assessed as inhibition of IBMX-induced cAMP accumulation after 15 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled receptor 4(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM123510(US8748435, 35)
Affinity DataIC50:  67nMAssay Description:Antagonist activity at human GPR4 expressed in human HeLa cells assessed as inhibition of IBMX-induced cAMP accumulation after 15 mins in presence of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed