BDBM124350 CHEMBL2071607::US8759532, 1
SMILES FC(F)(F)c1cccnc1Oc1ccc(Nc2nc3ccc(cc3[nH]2)C#N)cc1
InChI Key InChIKey=GAHCTGQCJXQYNK-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 124350
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Amgen
US Patent
Amgen
US Patent
Affinity DataIC50: 112nMT: 2°CAssay Description:To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...More data for this Ligand-Target Pair
Affinity DataIC50: 1.21E+4nMAssay Description:Inhibition of CK1alpha by Lance assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.77E+3nMAssay Description:Inhibition of CK1delta by Lance assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6.56E+3nMAssay Description:Inhibition of CK1gamma2 expressed in HEK293 cells assessed as inhibition of LRP6 Thr1479 phosphorylation by immunoblottingMore data for this Ligand-Target Pair
Affinity DataIC50: 3.08E+4nMAssay Description:Inhibition of GSK3beta by AlphaScreen assayMore data for this Ligand-Target Pair