BDBM124350 CHEMBL2071607::US8759532, 1

SMILES FC(F)(F)c1cccnc1Oc1ccc(Nc2nc3ccc(cc3[nH]2)C#N)cc1

InChI Key InChIKey=GAHCTGQCJXQYNK-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 124350   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM124350(CHEMBL2071607 | US8759532, 1)
Affinity DataIC50:  112nMT: 2°CAssay Description:To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCasein kinase I isoform alpha(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM124350(CHEMBL2071607 | US8759532, 1)
Affinity DataIC50:  1.21E+4nMAssay Description:Inhibition of CK1alpha by Lance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform delta(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM124350(CHEMBL2071607 | US8759532, 1)
Affinity DataIC50:  5.77E+3nMAssay Description:Inhibition of CK1delta by Lance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform gamma-2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM124350(CHEMBL2071607 | US8759532, 1)
Affinity DataIC50:  6.56E+3nMAssay Description:Inhibition of CK1gamma2 expressed in HEK293 cells assessed as inhibition of LRP6 Thr1479 phosphorylation by immunoblottingMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM124350(CHEMBL2071607 | US8759532, 1)
Affinity DataIC50:  3.08E+4nMAssay Description:Inhibition of GSK3beta by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed