BDBM127440 US8791131, 214

SMILES C[C@@H](O)C(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2ccc(nc2)N(C)C)n(C)c1=O

InChI Key InChIKey=WRJSXCWYFAJORN-OAHLLOKOSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 127440   

LigandPNGBDBM127440(US8791131, 214)
Affinity DataKi:  0.397nM ΔG°:  -12.8kcal/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM127440(US8791131, 214)
Affinity DataKi:  1.74nM ΔG°:  -11.9kcal/molepH: 7.5 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...More data for this Ligand-Target Pair
In DepthDetails US Patent