BDBM138364 US10278929, Compound 12::US11337935, Compound 12::US8877795, 12

SMILES FC(F)(F)c1cccc(\C=C2/SC(=O)NC2=O)c1

InChI Key InChIKey=NGJLOFCOEOHFKQ-YVMONPNESA-N

Data  1 KI  5 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 138364   

TargetCDGSH iron-sulfur domain-containing protein 1(Homo sapiens (Human))
West Virginia University

Curated by ChEMBL
LigandPNGBDBM138364(US10278929, Compound 12 | US11337935, Compound 12 ...)
Affinity DataKi:  297nMAssay Description:Displacement of [3H]rosiglitazone from recombinant human C-terminal His-tagged MitoNEET cytosolic domain (32 to 108 residues) expressed in Escherichi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Leland Stanford Junior University

US Patent
LigandPNGBDBM138364(US10278929, Compound 12 | US11337935, Compound 12 ...)
Affinity DataIC50:  815nMAssay Description:Table 3: The FP assay was then adapted for HTS and used to screen 120,000 small molecule library for compounds that displaced probe 5 from the T4 bin...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM138364(US10278929, Compound 12 | US11337935, Compound 12 ...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human recombinant full length His-tagged PIM-1 expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Leland Stanford Junior University

US Patent
LigandPNGBDBM138364(US10278929, Compound 12 | US11337935, Compound 12 ...)
Affinity DataIC50:  815nMAssay Description:The FP assay was then adapted for HTS and used to screen a ˜120,000 member small molecule library for compounds that displaced the FP probe from the ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransthyretin(Homo sapiens (Human))
Leland Stanford Junior University

US Patent
LigandPNGBDBM138364(US10278929, Compound 12 | US11337935, Compound 12 ...)
Affinity DataIC50:  815nMAssay Description:The FP assay was then adapted for HTS and used to screen ~120,000 small molecule library for compounds that displaced probe 5 from the T4 binding of ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCDGSH iron-sulfur domain-containing protein 1(Homo sapiens (Human))
West Virginia University

Curated by ChEMBL
LigandPNGBDBM138364(US10278929, Compound 12 | US11337935, Compound 12 ...)
Affinity DataIC50:  6.94E+3nMAssay Description:Displacement of [3H]rosiglitazone from recombinant human C-terminal His-tagged MitoNEET cytosolic domain (32 to 108 residues) expressed in Escherichi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed