BDBM140360 US10947243, Example 85::US8912173, 85::US9914735, Example 85

SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc2nc(C)sc2c1)[C@H]1CNC(=O)C1

InChI Key InChIKey=BIGXOFQDFCWJGU-CXAGYDPISA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 140360   

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM140360(US10947243, Example 85 | US8912173, 85 | US9914735...)
Affinity DataIC50:  0.200nMpH: 7.5 T: 2°CAssay Description:Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM140360(US10947243, Example 85 | US8912173, 85 | US9914735...)
Affinity DataIC50:  2nMAssay Description:Human GSK3beta (expressed and prified from SF21 cells) is obtained from the University Dundee/Scotland (Dr. James Hastie—Dept. of Biochemistry) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM140360(US10947243, Example 85 | US8912173, 85 | US9914735...)
Affinity DataIC50:  460nMAssay Description:Recombinant human Aurora B (amino acids 1-344, clone number DU1773, Molecular weight 40.2 kDa, University of Dundee) was expressed as a fusion protei...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM140360(US10947243, Example 85 | US8912173, 85 | US9914735...)
Affinity DataIC50:  321nMAssay Description:FLT3 is obtained from Invitrogen in 50 mM Tris (pH7.5); 100 mM NaCl; 0.05 mM EDTA, 0.05% NP-40, 2 mM DTT; 50% Glycerol # PV3182; Lot 286671; sequence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM140360(US10947243, Example 85 | US8912173, 85 | US9914735...)
Affinity DataIC50:  6.82E+3nMAssay Description:FLT3 is obtained from Invitrogen in 50 mM Tris (pH7.5); 100 mM NaCl; 0.05 mM EDTA, 0.05% NP-40, 2 mM DTT; 50% Glycerol # PV3182; Lot 286671; sequence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK [342-635](Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM140360(US10947243, Example 85 | US8912173, 85 | US9914735...)
Affinity DataIC50:  2nMAssay Description:Human GSK3beta (expressed and prified from SF21 cells) is obtained from the University Dundee/Scotland (Dr. James Hastie—Dept. of Biochemistry) in 50...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM140360(US10947243, Example 85 | US8912173, 85 | US9914735...)
Affinity DataIC50:  460nMAssay Description:Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM140360(US10947243, Example 85 | US8912173, 85 | US9914735...)
Affinity DataIC50:  321nMAssay Description:Recombinant human Aurora B (amino acids 1-344, clone number DU1773, Molecular weight 40.2 kDa, University of Dundee) was expressed as a fusion protei...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM140360(US10947243, Example 85 | US8912173, 85 | US9914735...)
Affinity DataIC50:  6.82E+3nMAssay Description:Human GSK3beta (expressed and prified from SF21 cells) is obtained from the University Dundee/Scotland (Dr. James Hastie—Dept. of Biochemistry) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent