BDBM142744 US8937095, 6

SMILES CCNC(=O)C#Cc1ccc2\C(=C(\Nc3ccc(CN(C)C)cc3)c3ccccc3)C(=O)Nc2c1

InChI Key InChIKey=FLBNLJLONKAPLR-DQSJHHFOSA-N

Data  8 IC50

PDB links: 3 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 142744   

TargetAurora kinase B-B(Xenopus laevis (African clawed frog))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM142744(US8937095, 6)
Affinity DataIC50:  3nMpH: 7.6Assay Description:The ATP-KM value of the complex is 61 uM. The kinase assays are run in the presence of 100 uM ATP using 10 uM of a substrate peptide. pAUB-IN847 was ...More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM142744(US8937095, 6)
Affinity DataIC50:  25nMpH: 7.6Assay Description:The ATP-KM value of the complex is 61 uM. The kinase assays are run in the presence of 100 uM ATP using 10 uM of a substrate peptide. pAUB-IN847 was ...More data for this Ligand-Target Pair
TargetAurora kinase B(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM142744(US8937095, 6)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant human full-length His-tagged Aurora B expressed in baculovirus expression system using 5-FAM-LRRASLG-CONH2 as substrate pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B-B(Xenopus laevis (African clawed frog))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM142744(US8937095, 6)
Affinity DataIC50:  3nMAssay Description:Inhibition of Xenopus laevis Aurora Kinase BMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM142744(US8937095, 6)
Affinity DataIC50:  25nMAssay Description:Inhibition of human MEK1More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM142744(US8937095, 6)
Affinity DataIC50:  4nMAssay Description:Inhibition of human MEK2More data for this Ligand-Target Pair
TargetAurora kinase A-A(Xenopus laevis)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM142744(US8937095, 6)
Affinity DataIC50:  25nMAssay Description:Inhibition of Xenopus laevis Aurora Kinase AMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAurora kinase A(Homo sapiens (Human))
University Of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM142744(US8937095, 6)
Affinity DataIC50:  25nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed