BDBM14322 2-Aminoquinoline 1::2-aminoquinoline::CHEMBL61236::Fragment 19::Quinolin-2-amine::fragment 2 (J. med. chem.,50,1116)
SMILES Nc1ccc2ccccc2n1
InChI Key InChIKey=GCMNJUJAKQGROZ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 18 hits for monomerid = 14322
Target5-hydroxytryptamine receptor 3A(RAT)
Virginia Commonwealth University
Curated by PDSP Ki Database
Virginia Commonwealth University
Curated by PDSP Ki Database
Affinity DataKi: 7.90E+4nMAssay Description:Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor of rat cortical membrane homogenatesMore data for this Ligand-Target Pair
Affinity DataKi: 2.20E+5nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
Affinity DataKi: 4.28E+5nMAssay Description:Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...More data for this Ligand-Target Pair
Affinity DataKi: 5.60E+5nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
TargetNitric oxide synthase oxygenase [E25A,E26A,E316A](Bacillus subtilis)
University Of California Irvine
University Of California Irvine
Affinity DataIC50: 2.73E+4nMAssay Description:Reactions were carried out using the buffered solution reported for the three-component reaction. The bBiDomain reactions included 100 nm bBiDomain a...More data for this Ligand-Target Pair
TargetNitric oxide synthase oxygenase [E25A,E26A,I218V,E316A](Bacillus subtilis)
University Of California Irvine
University Of California Irvine
Affinity DataIC50: 6.39E+4nMAssay Description:Reactions were carried out using the buffered solution reported for the three-component reaction. The bBiDomain reactions included 100 nm bBiDomain a...More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibitory activity against inducible nitric oxide synthase (iNOS)More data for this Ligand-Target Pair
Affinity DataKd: 9.00E+5nMAssay Description:Binding affinity to BACE1 after 90 seconds by surface plasmon resonance assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8.00E+5nMAssay Description:Inhibition of BACE1 using 19F-labeled EVNLDAEF(CF3) as substrate after 20 mins by NMR spectrometeryMore data for this Ligand-Target Pair
Affinity DataKd: 9.00E+5nMAssay Description:Binding affinity to BACE1 by surface plasmon resonance methodMore data for this Ligand-Target Pair
Affinity DatapH: 5.0 T: 2°CAssay Description:Activity of BACE-1 was measured by monitoring the cleavage of its peptide substrate on a Fluoroskan Ascent plate reader with excitation and emission ...More data for this Ligand-Target Pair
Affinity DataKd: 1.25E+5nMAssay Description:Displacement of PRP-1 peptide from mouse Tec kinase SH3 domain by fluorescence polarizationMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+6nMAssay Description:Displacement of PRP-2 peptide from human Hck kinase SH3 domain by fluorescence polarizationMore data for this Ligand-Target Pair
Affinity DataEC50: 1.60E+5nMAssay Description:Displacement of PRP-1 peptide from mouse Tec kinase SH3 domain by fluorescence polarizationMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+6nMpH: 5.0 T: 2°CAssay Description:Activity of BACE-1 was measured by monitoring the cleavage of its peptide substrate on a Fluoroskan Ascent plate reader with excitation and emission ...More data for this Ligand-Target Pair
Affinity DataKd: 4.88E+5nMAssay Description:Binding affinity to immobilized recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cel...More data for this Ligand-Target Pair
Affinity DataEC50: 1.50E+5nMAssay Description:Displacement of PRP-1 peptide from human Nck kinase SH3 domain by fluorescence polarizationMore data for this Ligand-Target Pair