BDBM144390 US8969376, 1.006

SMILES Cc1nc2ccc(F)cc2nc1-c1cc2nc(cc(NCC(C)(C)O)n2n1)N1CC[C@@H](F)C1

InChI Key InChIKey=PUJFXPWIBOJQHB-OAHLLOKOSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 144390   

TargetPhosphodiesterase(Bos taurus (Bovine))
Mitsubishi Tanabe Pharma

US Patent
LigandPNGBDBM144390(US8969376, 1.006)
Affinity DataIC50:  0.0900nMpH: 8.0Assay Description:The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM144390(US8969376, 1.006)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDE7B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM144390(US8969376, 1.006)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDE3A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM144390(US8969376, 1.006)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM144390(US8969376, 1.006)
Affinity DataIC50:  289nMAssay Description:Inhibition of PDE4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetO43924/P16499/P18545/P35913/P51160/Q13956(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM144390(US8969376, 1.006)
Affinity DataIC50:  561nMAssay Description:Inhibition of PDE6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM144390(US8969376, 1.006)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDE9A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM144390(US8969376, 1.006)
Affinity DataIC50:  0.0620nMAssay Description:Inhibition of human N-terminal FLAG-tagged PDE10A (1 to 90 residues) expressed in using African green monkey COS7 cells using [3H]cAMP or [3H]cGMP as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM144390(US8969376, 1.006)
Affinity DataIC50:  437nMAssay Description:Inhibition of PDE5A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM144390(US8969376, 1.006)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDE11A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM144390(US8969376, 1.006)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDE8A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed