BDBM14827 (+/-)1-[5-Chloro-2-(tetrahydro-pyran-4-yloxy)-phenyl]-3-(5-cyano-pyrazin-2-yl)-urea::3-[5-chloro-2-(oxan-4-yloxy)phenyl]-1-(5-cyanopyrazin-2-yl)urea::urea-based inhibitor 2b

SMILES Clc1ccc(OC2CCOCC2)c(NC(=O)Nc2cnc(cn2)C#N)c1

InChI Key InChIKey=GELSSERXHLOALO-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 14827   

TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM14827((+/-)1-[5-Chloro-2-(tetrahydro-pyran-4-yloxy)-phen...)
Affinity DataIC50:  5nMpH: 7.4 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 5uM ATP/[gamma-33P] ATP. 33P incor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed