BDBM14828 (+/-)1-[5-Chloro-2-(1-methyl-piperidin-4-yloxy)-phenyl]-3-(5-cyano-pyrazin-2-yl)-urea::3-{5-chloro-2-[(1-methylpiperidin-4-yl)oxy]phenyl}-1-(5-cyanopyrazin-2-yl)urea::urea-based inhibitor 2c

SMILES CN1CCC(CC1)Oc1ccc(Cl)cc1NC(=O)Nc1cnc(cn1)C#N

InChI Key InChIKey=WTQRLVNDANHFDI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 14828   

TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM14828((+/-)1-[5-Chloro-2-(1-methyl-piperidin-4-yloxy)-ph...)
Affinity DataIC50:  10nMpH: 7.4 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 5uM ATP/[gamma-33P] ATP. 33P incor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed