BDBM14839 1-(5-tert-Butyl-2-phenyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea::3-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea::BIRB-796 Analog 33::CHEMBL318810::diaryl urea compound 8
SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)n(n1)-c1ccccc1
InChI Key InChIKey=IDTKLCNLVPKYPA-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 14839
Affinity DataKd: 0.0900nMpH: 7.0 T: 2°CAssay Description:The exchange curve assays were run as two half-reactions using an SLM Aminco Bowman Series 2 model SQ-340 fluorescence detector. In the first half re...More data for this Ligand-Target Pair
Affinity DataKd: 0.230nMpH: 7.0 T: 2°CAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University
Curated by ChEMBL
Boston University
Curated by ChEMBL
Affinity DataKd: 0.100nMAssay Description:Binding affinity to P38 mitogen activated protein kinase (unknown origin)More data for this Ligand-Target Pair
Affinity DataKon: 0.0000150M-1s-1Assay Description:Binding affinity for Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
Affinity DataKon: 0.0000150M-1s-1 Koff: 1.54E+5s-1Assay Description:Binding affinity for Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
Affinity DataKd: 0.0970nMAssay Description:Binding affinity for Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair