BDBM153227 US10421760, Comparative Example 12::US8993756, 20-9

SMILES C=CC(=O)Nc1cccc(c1)-c1ncnc2[nH]cc(-c3ccccc3)c12

InChI Key InChIKey=ZZQAUPMZTTVWNS-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 153227   

TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM153227(US10421760, Comparative Example 12 | US8993756, 20...)
Affinity DataIC50:  0.0160nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM153227(US10421760, Comparative Example 12 | US8993756, 20...)
Affinity DataIC50: >1.50E+3nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM153227(US10421760, Comparative Example 12 | US8993756, 20...)
Affinity DataIC50:  0.0900nMAssay Description:JAK3: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a s...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM153227(US10421760, Comparative Example 12 | US8993756, 20...)
Affinity DataIC50: >1.00E+3nMAssay Description:JAK 2: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM153227(US10421760, Comparative Example 12 | US8993756, 20...)
Affinity DataIC50: >1.00E+3nMAssay Description:JAK 1: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...More data for this Ligand-Target Pair
In DepthDetails US Patent