BDBM154061 US9012443, 57

SMILES FC(F)(F)c1ccc(cc1Cl)-c1nccc2cc(ccc12)S(=O)(=O)Nc1ncns1

InChI Key InChIKey=PMBCGKYITRCKIW-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 154061   

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM154061(US9012443, 57)
Affinity DataKi:  2.00E+3nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in HEK293 cells after 45 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM154061(US9012443, 57)
Affinity DataIC50:  2.70E+4nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells incubated for 3 to 5 mins at -50 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM154061(US9012443, 57)
Affinity DataIC50:  590nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM154061(US9012443, 57)
Affinity DataIC50:  220nMAssay Description:293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks Quattro automated electrop...More data for this Ligand-Target Pair
In DepthDetails US Patent