BDBM166646 4-((4-(furan-2-carboxamido)phenyl)amino)-4-oxobutanoic acid (5)

SMILES OC(=O)CCC(=O)Nc1ccc(NC(=O)c2ccco2)cc1

InChI Key InChIKey=QTKDRUABFJMKRT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 166646   

TargetDNA gyrase subunit B(Staphylococcus aureus)
Birla Institute Of Technology

LigandPNGBDBM166646(4-((4-(furan-2-carboxamido)phenyl)amino)-4-oxobuta...)
Affinity DataIC50:  1.29E+4nMpH: 7.5Assay Description:Initially, equimolar quantities of about 0.5µM each of E. coli gyraseA and S. aureus gyraseB were incubated for a period of 45 min with salmon sperm ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Staphylococcus aureus)
Birla Institute Of Technology

LigandPNGBDBM166646(4-((4-(furan-2-carboxamido)phenyl)amino)-4-oxobuta...)
Affinity DataIC50:  1.29E+4nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase B ATPase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Birla Institute Of Technology & Science-Pilani

Curated by ChEMBL
LigandPNGBDBM166646(4-((4-(furan-2-carboxamido)phenyl)amino)-4-oxobuta...)
Affinity DataIC50:  3.13E+3nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase-mediated supercoiling of relaxed DNA using pBR 322 as substrate by agarose gel electrophoresis analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Staphylococcus aureus)
Birla Institute Of Technology

LigandPNGBDBM166646(4-((4-(furan-2-carboxamido)phenyl)amino)-4-oxobuta...)
Affinity DataIC50:  3.12E+3nMpH: 7.6 T: 2°CAssay Description:Supercoiling assay was performed using the commercially available kit (DNA gyrase supercoiling assay kit: SAS4001) from Inspiralis Pvt.limited, Norwi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed