BDBM17665 2-(2,6-difluorophenyl)-1-[(2,6-difluorophenyl)methyl]-4-methyl-1H-1,3-benzodiazole::CHEMBL293961::benzimidazole analogue, 1

SMILES Cc1cccc2n(Cc3c(F)cccc3F)c(nc12)-c1c(F)cccc1F

InChI Key InChIKey=JIYRSPUMGRIYBL-UHFFFAOYSA-N

Data  2 IC50  15 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 17665   

TargetGag-Pol polyprotein [600-1029,C879S]/[600-1159,C879S](Human immunodeficiency virus type 1)
Nci-Fcrdc

LigandPNGBDBM17665(2-(2,6-difluorophenyl)-1-[(2,6-difluorophenyl)meth...)
Affinity DataIC50:  200nMpH: 8.0 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM17665(2-(2,6-difluorophenyl)-1-[(2,6-difluorophenyl)meth...)
Affinity DataEC50:  440nMAssay Description:Inhibition of HIV-1 reverse transcriptase.More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM17665(2-(2,6-difluorophenyl)-1-[(2,6-difluorophenyl)meth...)
Affinity DataEC50:  2.30E+3nMAssay Description:Cross Resistance (antiviral activity) of the compound with Y188C (Nonnucleoside reverse transcriptase inhibitor) resistant HIV isolate from cytopathi...More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM17665(2-(2,6-difluorophenyl)-1-[(2,6-difluorophenyl)meth...)
Affinity DataIC50:  2.00E+5nMAssay Description:The quantity of compound required to reduce WT Reverse transcriptase activity by 50%More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM17665(2-(2,6-difluorophenyl)-1-[(2,6-difluorophenyl)meth...)
Affinity DataEC50:  300nMAssay Description:Cross Resistance (antiviral activity) of the compound with L100I (Nonnucleoside reverse transcriptase inhibitor) resistant HIV isolate from cytopathi...More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM17665(2-(2,6-difluorophenyl)-1-[(2,6-difluorophenyl)meth...)
Affinity DataEC50:  100nMAssay Description:Cross Resistance (antiviral activity) of the compound with L74V (Nonnucleoside reverse transcriptase inhibitor) resistant HIV isolate from cytopathic...More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM17665(2-(2,6-difluorophenyl)-1-[(2,6-difluorophenyl)meth...)
Affinity DataEC50:  2.00E+4nMAssay Description:Cross Resistance (antiviral activity) of the compound with V106A (Nonnucleoside reverse transcriptase inhibitor) resistant HIV isolate from cytopathi...More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM17665(2-(2,6-difluorophenyl)-1-[(2,6-difluorophenyl)meth...)
Affinity DataEC50:  2.80E+3nMAssay Description:Cross Resistance (antiviral activity) of the compound with V108I (Nonnucleoside reverse transcriptase inhibitor) resistant HIV isolate vMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM17665(2-(2,6-difluorophenyl)-1-[(2,6-difluorophenyl)meth...)
Affinity DataEC50:  1.67E+4nMAssay Description:Cross Resistance(antiviral activity) of the compound with K101E (Nonnucleoside reverse transcriptase inhibitor) resistant HIV isolate from cytopathic...More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM17665(2-(2,6-difluorophenyl)-1-[(2,6-difluorophenyl)meth...)
Affinity DataEC50:  8.10E+3nMAssay Description:Cross Resistance (antiviral activity) of the compound with K103N (Nonnucleoside reverse transcriptase inhibitor) resistant HIV isolate from cytopathi...More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM17665(2-(2,6-difluorophenyl)-1-[(2,6-difluorophenyl)meth...)
Affinity DataEC50:  3.50E+3nMAssay Description:Cross Resistance (antiviral activity) of the compound with 4xAZT/Y181C (Nonnucleoside reverse transcriptase inhibitor) resistant HIV isolate from cyt...More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM17665(2-(2,6-difluorophenyl)-1-[(2,6-difluorophenyl)meth...)
Affinity DataEC50:  500nMAssay Description:Cross Resistance (antiviral activity) of the compound with V179D (Nonnucleoside reverse transcriptase inhibitor) resistant HIV isolate from cytopathi...More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM17665(2-(2,6-difluorophenyl)-1-[(2,6-difluorophenyl)meth...)
Affinity DataEC50:  100nMAssay Description:Cross Resistance (antiviral activity) of the compound with 4xAZT (Nonnucleoside reverse transcriptase inhibitor) resistant HIV isolate from cytopathi...More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM17665(2-(2,6-difluorophenyl)-1-[(2,6-difluorophenyl)meth...)
Affinity DataEC50:  6.00E+3nMAssay Description:Cross Resistance (antiviral activity) of the compound with Y181C (Nonnucleoside reverse transcriptase inhibitor) resistant HIV isolate from cytopathi...More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM17665(2-(2,6-difluorophenyl)-1-[(2,6-difluorophenyl)meth...)
Affinity DataEC50:  500nMAssay Description:Cross Resistance (antiviral activity) of the compound with NL4-3(WT) NNRTI (Nonnucleoside reverse transcriptase inhibitor) resistant HIV isolate from...More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM17665(2-(2,6-difluorophenyl)-1-[(2,6-difluorophenyl)meth...)
Affinity DataEC50:  200nMAssay Description:Cross Resistance (antiviral activity) of the compound with 4xAZT/L100I (Nonnucleoside reverse transcriptase inhibitor) resistant HIV isolate from cyt...More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM17665(2-(2,6-difluorophenyl)-1-[(2,6-difluorophenyl)meth...)
Affinity DataEC50:  1.40E+3nMAssay Description:Cross Resistance (antiviral activity) of the compound with A98G (Nonnucleoside reverse transcriptase inhibitor) resistant HIV isolate from cytopathic...More data for this Ligand-Target Pair