BDBM176836 US10307413, Compound 16::US10391089, Compound 16::US10980794, Cmpd No 16::US9675614, 16

SMILES OC(CNC(=O)c1cccc(NC2CCOCC2)c1)CN1CCc2ccccc2C1

InChI Key InChIKey=LAWDUEFJOJENIJ-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 176836   

TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Epizyme

US Patent
LigandPNGBDBM176836(US10307413, Compound 16 | US10391089, Compound 16 ...)
Affinity DataIC50: <100nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Epizyme

US Patent
LigandPNGBDBM176836(US10307413, Compound 16 | US10391089, Compound 16 ...)
Affinity DataIC50: <100nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Epizyme

US Patent
LigandPNGBDBM176836(US10307413, Compound 16 | US10391089, Compound 16 ...)
Affinity DataIC50: <100nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Epizyme

US Patent
LigandPNGBDBM176836(US10307413, Compound 16 | US10391089, Compound 16 ...)
Affinity DataIC50: <100nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB