BDBM18223 6-{3-[(2,4-diaminopyrimidin-5-yl)methyl]-4,5-dimethoxyphenyl}hex-5-ynoic acid::Diaminopyrimidine analogue, 3

SMILES COc1cc(cc(Cc2cnc(N)nc2N)c1OC)C#CCCCC(O)=O

InChI Key InChIKey=MDVRFMJVQMAYTM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 18223   

TargetDihydrofolate reductase(Pneumocystis carinii)
Harvard Medical School

LigandPNGBDBM18223(6-{3-[(2,4-diaminopyrimidin-5-yl)methyl]-4,5-dimet...)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Harvard Medical School

LigandPNGBDBM18223(6-{3-[(2,4-diaminopyrimidin-5-yl)methyl]-4,5-dimet...)
Affinity DataIC50:  5.00E+3nMAssay Description:Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Harvard Medical School

LigandPNGBDBM18223(6-{3-[(2,4-diaminopyrimidin-5-yl)methyl]-4,5-dimet...)
Affinity DataIC50:  2.40nMAssay Description:Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

LigandPNGBDBM18223(6-{3-[(2,4-diaminopyrimidin-5-yl)methyl]-4,5-dimet...)
Affinity DataIC50:  34nMAssay Description:Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed