BDBM18237 5-{2-bromo-5-[(2,4-diaminopyrimidin-5-yl)methyl]-3-methoxyphenyl}pent-4-ynoic acid::Diaminopyrimidine analogue, 22

SMILES COc1cc(Cc2cnc(N)nc2N)cc(C#CCCC(O)=O)c1Br

InChI Key InChIKey=DWQGRIVGUVJVRF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 18237   

TargetDihydrofolate reductase(Pneumocystis carinii)
Harvard Medical School

LigandPNGBDBM18237(5-{2-bromo-5-[(2,4-diaminopyrimidin-5-yl)methyl]-3...)
Affinity DataIC50:  71nMpH: 7.4 T: 2°CAssay Description:Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Harvard Medical School

LigandPNGBDBM18237(5-{2-bromo-5-[(2,4-diaminopyrimidin-5-yl)methyl]-3...)
Affinity DataIC50:  630nMAssay Description:Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Harvard Medical School

LigandPNGBDBM18237(5-{2-bromo-5-[(2,4-diaminopyrimidin-5-yl)methyl]-3...)
Affinity DataIC50:  0.470nMAssay Description:Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

LigandPNGBDBM18237(5-{2-bromo-5-[(2,4-diaminopyrimidin-5-yl)methyl]-3...)
Affinity DataIC50:  15nMAssay Description:Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed