BDBM18383 Alkyl substituted pyrrole compound, 29e::sodium (3R,5R)-7-[1-ethyl-3-(4-fluorophenyl)-4-methyl-5-{[(5-methylpyrazin-2-yl)methyl]carbamoyl}-1H-pyrrol-2-yl]-3,5-dihydroxyheptanoate

SMILES CCn1c(CC[C@@H](O)C[C@@H](O)CC([O-])=O)c(c(C)c1C(=O)NCc1cnc(C)cn1)-c1ccc(F)cc1

InChI Key InChIKey=XOXXJOLIUVJJAA-FGZHOGPDSA-M

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 18383   

Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Pfizer

LigandPNGBDBM18383(Alkyl substituted pyrrole compound, 29e | sodium (...)
Affinity DataIC50:  4.70nMpH: 7.2 T: 2°CAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed