BDBM18510 5-{3-[(2,4-diaminopyrimidin-5-yl)methyl]-4-methoxyphenoxy}pentanoic acid::CHEMBL37520::Diaminopyrimidine, 22

SMILES COc1ccc(OCCCCC(O)=O)cc1Cc1cnc(N)nc1N

InChI Key InChIKey=ALDCXILJAYAUTH-UHFFFAOYSA-N

Data  13 IC50

PDB links: 4 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 18510   

TargetDihydrofolate reductase(Bacillus cereus (ATCC 14579))
University Of Connecticut At Storrs

LigandPNGBDBM18510(5-{3-[(2,4-diaminopyrimidin-5-yl)methyl]-4-methoxy...)
Affinity DataIC50:  7.37E+4nMpH: 7.0 T: 2°CAssay Description:Enzyme activity assays were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over a period of severa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18510(5-{3-[(2,4-diaminopyrimidin-5-yl)methyl]-4-methoxy...)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of partially purified dihydrofolate reductase (DHFR) from rat liverMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18510(5-{3-[(2,4-diaminopyrimidin-5-yl)methyl]-4-methoxy...)
Affinity DataIC50:  110nMAssay Description:Inhibition of partially purified dihydrofolate reductase (DHFR) from Toxoplasma gondii (Tg)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18510(5-{3-[(2,4-diaminopyrimidin-5-yl)methyl]-4-methoxy...)
Affinity DataIC50:  49nMAssay Description:In vitro inhibition of Pneumocystis carinii (Pc) dihydrofolate reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18510(5-{3-[(2,4-diaminopyrimidin-5-yl)methyl]-4-methoxy...)
Affinity DataIC50:  5.80nMAssay Description:Inhibition of partially purified dihydrofolate reductase (DHFR) from Mycobacterium avium (Ma)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18510(5-{3-[(2,4-diaminopyrimidin-5-yl)methyl]-4-methoxy...)
Affinity DataIC50:  110nMAssay Description:Inhibitory activity against Dihydrohydrofolate reductase(DHFR) of Toxoplasma gondiiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18510(5-{3-[(2,4-diaminopyrimidin-5-yl)methyl]-4-methoxy...)
Affinity DataIC50:  4.40nMAssay Description:Concentration required to inhibit the Mycobacterium avium Dihydrofolate reductase by 50% was determinedMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Mycobacterium avium)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18510(5-{3-[(2,4-diaminopyrimidin-5-yl)methyl]-4-methoxy...)
Affinity DataIC50:  5.80nMAssay Description:Inhibition of Dihydrohydrofolate reductase(DHFR) of Mycobacterium aviumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18510(5-{3-[(2,4-diaminopyrimidin-5-yl)methyl]-4-methoxy...)
Affinity DataIC50:  4.60E+3nMAssay Description:Inhibition Dihydrohydrofolate reductase(DHFR) of rat liverMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18510(5-{3-[(2,4-diaminopyrimidin-5-yl)methyl]-4-methoxy...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibitory concentration against dihdrofolate reductace enzyme of Cryptosporidium parvum of bovine originMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18510(5-{3-[(2,4-diaminopyrimidin-5-yl)methyl]-4-methoxy...)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibitory concentration against dihdrofolate reductace enzyme of humansMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18510(5-{3-[(2,4-diaminopyrimidin-5-yl)methyl]-4-methoxy...)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibitory concentration against dihdrofolate reductace enzyme of Cryptosporidium parvum of human originMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Pneumocystis carinii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18510(5-{3-[(2,4-diaminopyrimidin-5-yl)methyl]-4-methoxy...)
Affinity DataIC50:  54nMAssay Description:Inhibition of Dihydrohydrofolate reductase(DHFR) of Pneumocystis cariniiMore data for this Ligand-Target Pair