BDBM18520 6-(1-Pyrrolidine)quinolin-2(1H)-one, 4e::6-[(2R,5R)-2-(hydroxymethyl)-5-methylpyrrolidin-1-yl]-4-(trifluoromethyl)-1,2-dihydroquinolin-2-one

SMILES C[C@@H]1CC[C@H](CO)N1c1ccc2[nH]c(=O)cc(c2c1)C(F)(F)F

InChI Key InChIKey=RJQYEUKBEQAJBR-MWLCHTKSSA-N

Data  1 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 18520   

TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18520(6-(1-Pyrrolidine)quinolin-2(1H)-one, 4e | 6-[(2R,5...)
Affinity DataKi:  70nM ΔG°:  -10.1kcal/mole EC50:  21nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed