BDBM18786 5-(3-chlorophenyl)-6-(3-phenylpropyl)pyrimidine-2,4-diamine::CHEMBL21921::P31
SMILES Nc1nc(N)c(c(CCCc2ccccc2)n1)-c1cccc(Cl)c1
InChI Key InChIKey=CZDYZPVAAIFLQU-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 15 hits for monomerid = 18786
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium vivax (malaria parasite P. vivax))
National Center For Genetic Engineering And Biotechnology At Thailand
National Center For Genetic Engineering And Biotechnology At Thailand
Affinity DataKi: 0.770nM ΔG°: -12.4kcal/mole IC50: 2.38E+3nMpH: 7.0 T: 2°CAssay Description:Nineteen Pyr analogs were studied for their inhibition activity against cells expressing either WT or SP21 mutant PvDHFR-TS. The assays were conducte...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
National Center For Genetic Engineering And Biotechnology At Thailand
Curated by ChEMBL
National Center For Genetic Engineering And Biotechnology At Thailand
Curated by ChEMBL
Affinity DataKi: 1.20nMAssay Description:Binding affinity towards wild-type dihydrofolate reductase of Plasmodium falciparum.More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
National Center For Genetic Engineering And Biotechnology At Thailand
Curated by ChEMBL
National Center For Genetic Engineering And Biotechnology At Thailand
Curated by ChEMBL
Affinity DataKi: 1.20nMAssay Description:Inhibition of the wild-type dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase [1-238,S58R,S117N](Plasmodium vivax (malaria parasite P. vivax))
National Center For Genetic Engineering And Biotechnology At Thailand
National Center For Genetic Engineering And Biotechnology At Thailand
Affinity DataKi: 1.32nM IC50: 1.39E+4nMAssay Description:Nineteen Pyr analogs were studied for their inhibition activity against cells expressing either WT or SP21 mutant PvDHFR-TS. The assays were conducte...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
National Center For Genetic Engineering And Biotechnology At Thailand
Curated by ChEMBL
National Center For Genetic Engineering And Biotechnology At Thailand
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Binding affinity towards mutant dihydrofolate reductase (N51I+C59R+S108N DHFR) of Plasmodium falciparumMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
National Center For Genetic Engineering And Biotechnology At Thailand
Curated by ChEMBL
National Center For Genetic Engineering And Biotechnology At Thailand
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Binding affinity towards mutant dihydrofolate reductase (N51I+C59R+S108N+I164L DHFR) of Plasmodium falciparumMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
National Center For Genetic Engineering And Biotechnology At Thailand
Curated by ChEMBL
National Center For Genetic Engineering And Biotechnology At Thailand
Curated by ChEMBL
Affinity DataKi: 2.20nMAssay Description:Binding affinity towards mutant dihydrofolate reductase (C59R+S108N+I164L DHFR) of Plasmodium falciparumMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
National Center For Genetic Engineering And Biotechnology At Thailand
Curated by ChEMBL
National Center For Genetic Engineering And Biotechnology At Thailand
Curated by ChEMBL
Affinity DataKi: 3nMAssay Description:Inhibition of the S108N mutant of dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
National Center For Genetic Engineering And Biotechnology At Thailand
Curated by ChEMBL
National Center For Genetic Engineering And Biotechnology At Thailand
Curated by ChEMBL
Affinity DataKi: 4.20nMAssay Description:Inhibition of the C59R+S108N mutant of dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
National Center For Genetic Engineering And Biotechnology At Thailand
Curated by ChEMBL
National Center For Genetic Engineering And Biotechnology At Thailand
Curated by ChEMBL
Affinity DataKi: 42nMAssay Description:Inhibition constant against Plasmodium falciparum dihydrofolate reductaseChecked by AuthorMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
National Center For Genetic Engineering And Biotechnology At Thailand
Curated by ChEMBL
National Center For Genetic Engineering And Biotechnology At Thailand
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Antiplasmodial activity (IC50) against Plasmodium falciparum Clone with mutant enzyme C59R+S108N- pfDihydrofolate reductase (K1CB1)More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
National Center For Genetic Engineering And Biotechnology At Thailand
Curated by ChEMBL
National Center For Genetic Engineering And Biotechnology At Thailand
Curated by ChEMBL
Affinity DataIC50: 4.30E+3nMAssay Description:In vitro anti-plasmodial activity against Plasmodium falciparum with mutant N51I+C59R+S108N (W2) dihydrofolate reductase.More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
National Center For Genetic Engineering And Biotechnology At Thailand
Curated by ChEMBL
National Center For Genetic Engineering And Biotechnology At Thailand
Curated by ChEMBL
Affinity DataIC50: 670nMAssay Description:In vitro anti-plasmodial activity against Plasmodium falciparum with wild type dihydrofolate reductase (TM4/8.2).More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
National Center For Genetic Engineering And Biotechnology At Thailand
Curated by ChEMBL
National Center For Genetic Engineering And Biotechnology At Thailand
Curated by ChEMBL
Affinity DataIC50: 3.60E+3nMAssay Description:In vitro anti-plasmodial activity against Plasmodium falciparum with mutant C59R+S108N+I164L (Csl-2) dihydrofolate reductase.More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
National Center For Genetic Engineering And Biotechnology At Thailand
Curated by ChEMBL
National Center For Genetic Engineering And Biotechnology At Thailand
Curated by ChEMBL
Affinity DataIC50: 5.70E+3nMAssay Description:In vitro anti-plasmodial activity against Plasmodium falciparum with mutant CN51I+C59R+S108N+I164L (V1/S) dihydrofolate reductase.More data for this Ligand-Target Pair